ChemicalBook > CAS DataBase List > (S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID

(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID

Product Name
(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID
CAS No.
736131-48-9
Chemical Name
(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID
Synonyms
S-2-Me-PHA;S-2-CH3-PHA;H-b-Phe(2-Me)-OH;RARECHEM LK HC T303;H-BETA-PHE(2-ME)-OH;H-L-beta-Phe(2-Me)-OH;H-D-PHG(2-ME)-(C*CH2)OH;H-(S)-beta-Phe(2-Me)-OH;2-Methyl-D-β-homophenylglycine;REF DUPL: H-L-beta-Phe(2-Me)-OH
CBNumber
CB4273215
Molecular Formula
C10H13NO2
Formula Weight
179.22
MOL File
736131-48-9.mol
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(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID Property

Boiling point:
326.3±30.0 °C(Predicted)
Density 
1.163±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.71±0.10(Predicted)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A614550
Product name
(S)-3-Amino-3-(2-methyl-phenyl)-propionicacid
Packaging
25mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
075077
Product name
(S)-3-Amino-3-(2-methylphenyl)propionic acid
Purity
95+%
Packaging
5g
Price
$751
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0034193
Product name
(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID
Purity
95.00%
Packaging
1G
Price
$857.01
Updated
2021/12/16
ChemPep
Product number
182872
Product name
H-β-Phe(2-Me)-OH
Packaging
5g
Price
$430
Updated
2021/12/16
Chem-Impex
Product number
15618
Product name
(S)-3-Amino-3-(2-methylphenyl)propionicacid,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$476
Updated
2021/12/16
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(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID Chemical Properties,Usage,Production

Uses

(S)-3-Amino-3-(2-methylphenyl)propionic acid is an amino acid derivative that can be used as a pharmaceutical intermediate or chemical reaction reagent.

Synthesis

21464-57-3

736131-48-9

1292457-13-6

Racemate 3-amino-3-(2-methylphenyl)-propionic acid (0.5 g, 2.41 mmol) was used as raw material and dissolved in tert-butyl methyl ether (t-BuOMe, 40 mL). Lipase PSIM (1.2 g, 30 mg/mL) and deionized water (430 μL, 24 mmol) were added, and the reaction mixture was placed in a thermostatic oscillator at 45°C for 7 hr. When the reaction reached 50% conversion, the enzyme was removed by filtration to terminate the reaction. The solvent was removed by distillation under reduced pressure to give unreacted (R)-3-amino-3-(2-methylphenyl)-propionic acid [240 mg, 48%; [α]D25 = +20.1° (c = 0.40, EtOH); ee = 99%]. The filtered enzyme was washed with distilled water (3 x 15 mL) and after evaporation of the aqueous phase, crystalline (S)-3-amino-3-(2-methylphenyl)-propionic acid {200 mg, 48%; [α]D25 = -25° (c = 0.15, H2O); melting point 235-237°C (recrystallized from water); ee = 98%} was obtained. Treatment of (S)-6 or (R)-3 (100 mg) with 18% hydrochloric acid (5 mL) afforded (S)-3-amino-3-(2-methylphenyl)-propionic acid hydrochloride {100 mg, 83%; [α]D25 = -6.4° (c = 0.55, H2O); ee = 99%} or (R)-3-amino-3-(2-methylphenyl)-propionic acid hydrochloride { 96 mg, 92%; [α]D25 = +6.4° (c = 0.3, H2O); ee = 99%}. The 1H NMR (400 MHz, CDCl3, 25°C, TMS) δ (ppm) data of (R)-3 were similar to those of (±)-3. Elemental analysis measured values: C, 69.50; H, 8.42; N, 6.75. 1H NMR (400 MHz, D2O) δ (ppm) data of (S)-6 was similar to that of (R)-6. Elemental analysis measured values: C, 67.02; H, 7.31; N, 7.82.

References

[1] Journal of Molecular Catalysis B: Enzymatic, 2013, vol. 93, p. 8 - 14

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Preparation Products

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View Lastest Price from (S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID manufacturers

Career Henan Chemical Co
Product
(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID 736131-48-9
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-09

736131-48-9, (S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACIDRelated Search:

FMOC-(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID (S)-3-AMINO-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID Boc-2-Methyl-D-beta-phenylalanine (S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID (S)-3-T-BUTOXYCARBONYL-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID,BOC-(S)-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID (R)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID Boc-3-Methyl-D-beta-phenylalanine FMOC-(R)-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID FMOC-(S)-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID (R)-3-AMINO-3-(3-METHYL-PHENYL)-PROPIONIC ACID (R)-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID BOC-(S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID,(S)-3-T-BUTOXYCARBONYL-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID FMOC-(S)-3-AMINO-3-(3-METHYL-PHENYL)-PROPIONIC ACID (S)-3-AMINO-3-(3-METHYL-PHENYL)-PROPIONIC ACID (R)-3-T-BUTOXYCARBONYL-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID,BOC-(R)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID FMOC-(R)-3-AMINO-3-(3-METHYL-PHENYL)-PROPIONIC ACID (R)-3-T-BUTOXYCARBONYL-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID,BOC-(R)-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID DL-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID

  • (S)-3-Amino-3-(2-methylphenyl)propionic scid
  • (3S)-3-amino-3-(2-methylphenyl)propanoic acid
  • H-D-PHG(2-ME)-(C*CH2)OH
  • H-BETA-PHE(2-ME)-OH
  • RARECHEM LK HC T303
  • (S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID
  • (S)-3-AMINO-3-O-TOLYL-PROPIONIC ACID
  • H-b-Phe(2-Me)-OH
  • S-2-CH3-PHA
  • (S)-3-amino-3-o-tolylpropanoic acid
  • H-L-beta-Phe(2-Me)-OH
  • REF DUPL: H-L-beta-Phe(2-Me)-OH
  • L-3-Amino-3-(2-methylphenyl)propanoic acid
  • S-2-Me-PHA
  • Benzenepropanoic acid, β-amino-2-methyl-, (βS)-
  • (3S)-3-amino-3-(2-methylphenyl)propanoicaci
  • (S)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID USP/EP/BP
  • 2-Methyl-D-β-homophenylglycine
  • H-(S)-beta-Phe(2-Me)-OH
  • 736131-48-9
  • B-Amino
  • 3-Amino-3-phenylpropionic Acid Analogs