3-Amino-3-(4-methylphenyl)propionic acid

Product Name: 3-Amino-3-(4-methylphenyl)propionic acid
CAS No.: 68208-18-4
Chemical Name: 3-Amino-3-(4-methylphenyl)propionic acid
Synonyms: RARECHEM AK HC T309;3-Amino-3-(4-methyL;DL--(p-Methylphenyl)alanine;DL-BETA-(P-METHYLPHENYL)ALANINE;3-Amino-3-(p-tolyl)propanoicacid;3-AMINO-3-(P-TOLYL)PROPIONIC ACID;3-AMINO-3-(4-TOLYL)PROPIONIC ACID;(S)-3-(1-aminopropyl)benzoic acid;3-(P-METHYLPHENYL)-DL-BETA-ALANINE;DL-3-Amino-3-p-tolyl-propionic acid
CBNumber: CB8292090
Molecular Formula: C10H13NO2
Formula Weight: 179.22
MOL File: 68208-18-4.mol

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3-Amino-3-(4-methylphenyl)propionic acid Property

Melting point:: 219 °C (dec.)(lit.)
Boiling point:: 311.75°C (rough estimate)
Density: 1.1248 (rough estimate)
refractive index: 1.4989 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.71±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 68208-18-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2345
Product name: 3-Amino-3-(p-tolyl)propionic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: A2345
Product name: 3-Amino-3-(p-tolyl)propionic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $342
Updated: 2025/07/31

TRC

Product number: A614628
Product name: 3-Amino-3-(4-methylphenyl)propanoicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA118211
Product name: 3-Amino-3-(4-methylphenyl)propanoic acid
Packaging: 250mg
Price: $57.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA118211
Product name: 3-Amino-3-(4-methylphenyl)propanoic acid
Packaging: 500mg
Price: $100
Updated: 2021/12/16

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3-Amino-3-(4-methylphenyl)propionic acid Chemical Properties,Usage,Production

Chemical Properties

white to off-white granular or crystalline powder

Synthesis

141-82-2

104-87-0

68208-18-4

To a 250 mL round bottom flask was added 50.0 g (0.42 mol) of p-toluylaldehyde, 47.6 g (0.46 mol) of malonic acid and 64.2 g (0.83 mol) of ammonium acetate dissolved in ethanol. The reaction mixture was heated to 80-90°C under stirring and refluxed for 7.5 hours. Upon completion of the reaction, the mixture was cooled to 0-5°C and stirred for 30 min, followed by filtration to afford 51.4 g of 3-amino-3-(p-tolyl)propionic acid (racemic mixture) as a white powder (68.9% isolated yield based on p-toluylaldehyde). The physical properties of 3-amino-3-(p-tolyl)propionic acid (racemic mixture) are as follows: 1H-NMR (δ, ppm, D2O + DCl): 2.30 (s, 3H), 3.04 (dd, 1H, J = 17.1, 6.8 Hz), 3.20 (dd, 1H, J = 17.1, 7.3 Hz), 4.74 (dd, 1H, J = 7.3, 6.8 Hz), 7.29 (d, 2H, J = 8.3 Hz), 7.36 (d, 2H, J = 8.3 Hz). 13C-NMR (δ, ppm, D2O + DCl): 23.4, 40.7, 54.4, 130.0, 133.0, 135.0, 143.1, 176.3. MS (EI) m/z: 179 (M+). MS (CI, i-C4H10) m/z: 180 (MH+). Elemental analysis: Calculated C, 67.02%; H, 7.31%; N, 7.82%. Measured values C, 67.05%; H, 7.40%; N, 7.66%.

References

[1] Patent: EP1621529, 2006, A1. Location in patent: Page/Page column 27-28
[2] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 252 - 268
[3] Advanced Synthesis and Catalysis, 2010, vol. 352, # 2-3, p. 395 - 406
[4] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 11, p. 1207 - 1212
[5] Bulletin de la Societe Chimique de France, 1987, # 6, p. 1079 - 1083

3-Amino-3-(4-methylphenyl)propionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-3-(4-methylphenyl)propionic acid Suppliers

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View Lastest Price from 3-Amino-3-(4-methylphenyl)propionic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Amino-3-(4-methylphenyl)propionic acid 68208-18-4
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Amino-3-(4-methylphenyl)propionic acid 68208-18-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Career Henan Chemical Co

Product: 3-Amino-3-(4-methylphenyl)propionic acid 68208-18-4
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

68208-18-4, 3-Amino-3-(4-methylphenyl)propionic acidRelated Search:

3,4'-DIAMINODIPHENYLMETHANE Propionic anhydride 3-Amino-3-phenylpropionic acid ALTRENOGEST β-Alanine 2,2-Bis(hydroxymethyl)propionic acid (S)-(+)-2-Phenylpropionic acid Glycine Propionic acid N,N-Dimethyl-1,4-phenylenediamine 3-AMINO-3-(4-METHYLPHENYL)PROPANOIC ACID HYDROCHLORIDE Tris(hydroxymethyl)aminomethane (R)-3-(FMOC-AMINO)-3-(4-METHYLPHENYL)PROPIONIC ACID (R)-3-AMINO-3-(2-METHYL-PHENYL)-PROPIONIC ACID (S)-3-(Boc-amino)-3-(3-methylphenyl)propionic acid, Boc-3-methyl-D-β-phenylalanine (R)-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID (S)-3-(BOC-AMINO)-3-(2-METHYLPHENYL)PROPIONIC ACID Boc-(S)-3-Amino-3-(4-methylphenyl)propionic acid

3-AMINO-3-(P-TOLYL)PROPIONIC ACID 98%

3-Amino-3-(p-tolyl)propionic acid,98%

3-AMINO-3-(4-METHYLPHENYL)PROPANOIC ACID

3-AMINO-3-(4-METHYLPHENYL)PROPIONIC ACID

3-AMINO-3-(P-TOLYL)PROPIONIC ACID

RARECHEM AK HC T309

Benzenepropanoic acid, .beta.-amino-4-methyl-

3-Amino-3-(<i>p</i>-tolyl)propionic Acid

DL-3-AMINO-3-(4-METHYL-PHENYL)-PROPIONIC ACID

DL-BETA-(P-METHYLPHENYL)ALANINE

3-AMINO-3-(4-METHYLPHENYL)PROPIONIC ACI&

DL--(p-Methylphenyl)alanine

3-(P-METHYLPHENYL)-DL-BETA-ALANINE

DL-3-Amino-3-p-tolyl-propionic acid

3-AMINO-3-(4-TOLYL)PROPIONIC ACID

(RS)-3-Amino-3-(4-methylphenyl)-propionic acid

3-Amino-3-(p-tolyl)propanoicacid

3-Amino-3-(p-tolyl)propionic Acid &gt

3-Amino-3-(4-methyL

Benzenepropanoic acid, β-amino-4-methyl-

(S)-3-(1-aminopropyl)benzoic acid

68208-18-4

H3CC6H4CHNH2CH2CO2H

Organic Building Blocks

Carboxylic Acids

Carbonyl Compounds

C10

Building Blocks

B-Amino

C10

Carbonyl Compounds

Carboxylic Acids