Taltobulin (trifluoroacetate)

Product Name: Taltobulin (trifluoroacetate)
CAS No.: 228266-41-9
Chemical Name: Taltobulin (trifluoroacetate)
Synonyms: SPA-110 trifluoroacetate;HTI-286 trifluoroacetate;Taltobulin (trifluoroacetate);HTI-286 TRIFLUOROACETATE;SPA-110 TRIFLUOROACETATE
CBNumber: CB42735540
Molecular Formula: C29H44F3N3O6
Formula Weight: 587.6713696
MOL File: 228266-41-9.mol

More

Less

Taltobulin (trifluoroacetate) Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 39 mg/mL (66.36 mM)
form: Solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-3787
Product name: Taltobulin(trifluoroacetate)
Purity: 99.96%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-3787
Product name: Taltobulin(trifluoroacetate)
Purity: 99.96%
Packaging: 10mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-3787
Product name: Taltobulin(trifluoroacetate)
Purity: 99.96%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

Crysdot

Product number: CD31002592
Product name: Taltobulintrifluoroacetate
Purity: 98+%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

Crysdot

Product number: CD31002592
Product name: Taltobulintrifluoroacetate
Purity: 98+%
Packaging: 50mg
Price: $910
Updated: 2021/12/16

More

Less

Taltobulin (trifluoroacetate) Chemical Properties,Usage,Production

Uses

Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].

in vivo

Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice^[1].
Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively^[1].

Animal Model:	Athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age)^[1]
Dosage:	1.6 mg/kg
Administration:	Administered i.v.;for 35 days
Result:	Growth of Lox tumors was inhibited by 96-98% on day 12 compared with vehicle-treated controls. Growth of KB-8-5 tumors was inhibited by 84% on day 14 compared with vehicle-treated controls. Growth of MX-1W tumors was inhibited by 97% compared with vehicle-treated controls. Growth of DLD-1 and HCT-15 tumors was inhibited by 80 and 66%, respectively.

IC 50

Traditional Cytotoxic Agents

References

[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571

Taltobulin (trifluoroacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Taltobulin (trifluoroacetate) Suppliers

China 23 United States 4 USA 1 Global 28

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Baoji Guokang Healthchem Co., Ltd.

Tel: +86-0917-3909592 +86-13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9215
Advantage: 58

More

Less

View Lastest Price from Taltobulin (trifluoroacetate) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Taltobulin trifluoroacetate 228266-41-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Taltobulin trifluoroacetate 228266-41-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

228266-41-9, Taltobulin (trifluoroacetate)Related Search:

HTI-286 trifluoroacetate

HTI-286 TRIFLUOROACETATE;SPA-110 TRIFLUOROACETATE

SPA-110 trifluoroacetate

Taltobulin (trifluoroacetate)

228266-41-9