L-Thyroxine-[L-Tyr-ring-13C6] hydrochloride

L-Thyroxine-[L-Tyr-ring-13C6] hydrochloride Property

Density 

2.636±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

Flash point:

9℃

storage temp. 

-20°C

form 

liquid

color 

White to off-white

Safety

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

L-Thyroxine-[L-Tyr-ring-13C6] hydrochloride Chemical Properties,Usage,Production

Uses

The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:

• Combination of hollow fiber-liquid-phase microextraction (HF-LPME) based sample preparation and liquid chromatography-tandem mass spectrometric (LC-MS/MS) determination of total thyroxine in serum samples
• Development of an LC-MS/MS method for the multi-residue analysis of melatonin, cortisol, triiodothyronine, thyroxine, and testosterone in r at serum samples following their dual liquid-liquid extraction
• Simultaneous determination of thyroxine by an isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method from human serum samples
• Estimation of thyroxine (T4) and triiodothyronine (T3) in r at cardiac tissue samples by a high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method following their derivatization
• Establishing and validating an LC-MS/MS-based method for the quantification of endogenous thyroid hormones, T4 and two of its T3 isomers, in tissue samples obtained from lamprey, following the enzymatic digestion and protein precipitation of the samples

General Description

Thyroxine or T4 is a thyroid hormone responsible for regulation of protein, fat, and carbohydrate metabolism as well as the proper development and differentiation of all cells of the human body. This internal standard and Certified Spiking Solution^? is suitable for quantitation of free and total T4 serum levels by LC-MS/MS for determination of hyper- or hypothyroidism and monitoring treatment with synthetic thyroid hormones.