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CAS:932749-62-7

Product Name
CAS:932749-62-7
CAS No.
932749-62-7
Chemical Name
CAS:932749-62-7
Synonyms
CAS:932749-62-7;HAT Inhibitor II;Histone Acetyltransferase Inhibitor II;Histone Acetyltransferase Inhibitor II (compound 2c);2,6-Bis(3-bromo-4-hydroxybenzylidene)cyclohexan-1-one;Cyclohexanone, 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-;Histone Acetyltransferase,HeLa,H2B-EYFP,acetylation,inhibit,Histone Acetyltransferase Inhibitor II,HAT,anti-acetylase,Inhibitor,HATs,histones
CBNumber
CB42741611
Molecular Formula
C20H16Br2O3
Formula Weight
464.15
MOL File
932749-62-7.mol
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CAS:932749-62-7 Property

Melting point:
201-202 °C(Solv: isopropanol (67-63-0); water (7732-18-5))
Boiling point:
580.8±50.0 °C(Predicted)
Density 
1.733±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
7.89±0.35(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19835
Product name
HAT Inhibitor II
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19835
Product name
HAT Inhibitor II
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19835
Product name
HAT Inhibitor II
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
Usbiological
Product number
451941
Product name
Histone Acetyltransferase Inhibitor II
Packaging
10mg
Price
$516
Updated
2021/12/16
TRC
Product number
H456345
Product name
HistoneAcetyltransferaseInhibitorII
Packaging
25mg
Price
$400
Updated
2021/12/16
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CAS:932749-62-7 Chemical Properties,Usage,Production

Uses

Histone Acetyltransferase Inhibitor II is a selective, cell-permeable p300/CBP HAT inhibitor, which may be used in the treatement of cystic fibrosis.

Biological Activity

hat inhibitor ii, a cell-permeable bis-arylidene cyclohexanone compound, selectively inhibits the histone acetyltransferase p300/creb-binding protein (cbp) with an ic50 value of 5 μm. it affects gcn5 and pcaf acetyltransferases only at much higher concentrations.histone acetyltransferase p300, a ubiquitously expressed global transcriptional coactivator, plays critical roles in a wide variety of cellular phenomena, involving in cell cycle control, differentiation, and apoptosis.

in vitro

hat inhibitor ii dose-dependently suppressed the proliferation of u251, u87, hs683 and shg44 cells. in hat inhibitor ii-treated u251 and shg44 cells, cell cycle arrest at the g2/m phase was triggered by hat inhibitor ii, significant levels of apoptosis, apoptotic body formation and dna fragmentation were induced, and cleavage of caspase-3, caspase-9 and parp were caused. additionally, hat inhibitor ii upregulated 965 genes and downregulated 984 genes in hat inhibitor ii-treated u251 cells [1].

in vivo

c57bl/6j mice were intraperitoneally administrated with hat inhibitor ii at a dose of 185 μg/g for 15 min. in muscle early postmortem, hat inhibitor ii inhibited protein acetylation, which reduced amp-activated protein kinase activation induced increase in the total acetylated proteins as well as glycolytic rate [2].

References

[1]. xu, l., li, z., tao, y., li, r., fang, f., & zhao, h. et al. histone acetyltransferase inhibitor ii induces apoptosis in glioma cell lines via the p53 signaling pathway. journal of experimental & clinical cancer research. 2014; 33:108.
[2]. li, q., li, z., lou, a., wang, z., zhang, d., & shen, q. histone acetyltransferase inhibitors antagonize amp-activated protein kinase in postmortem glycolysis. asian-australasian journal of animal sciences. 2016; 30(6): 857-864.

CAS:932749-62-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAS:932749-62-7 Suppliers

Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58

932749-62-7, CAS:932749-62-7Related Search:


  • CAS:932749-62-7
  • Histone Acetyltransferase Inhibitor II
  • HAT Inhibitor II
  • Cyclohexanone, 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-
  • Histone Acetyltransferase Inhibitor II (compound 2c)
  • 2,6-Bis(3-bromo-4-hydroxybenzylidene)cyclohexan-1-one
  • Histone Acetyltransferase,HeLa,H2B-EYFP,acetylation,inhibit,Histone Acetyltransferase Inhibitor II,HAT,anti-acetylase,Inhibitor,HATs,histones
  • 932749-62-7
  • C20H16Br2O3