1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone

Product Name: 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
CAS No.: 219315-22-7
Chemical Name: 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
Synonyms: Mitochondrial Fusion Promoter M1;Mitochondrial Fusion Promoter M1 >=95% (HPLC);Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem;(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol;1-(5-Chloro-2-hydroxyphenyl)ethanone (2,4,6-trichlorophenyl)hydrazone;1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone;Ethanone, 1-(5-chloro-2-hydroxyphenyl)-, 2-(2,4,6-trichlorophenyl)hydrazone;Mitochondrial Metabolism,ischemia,cardiac,inhibit,brain,damage,injury,reperfusion,Mitochondrial fusion promoter M 1,Mitochondrial fusion promoter M-1,Mitochondrial fusion promoter M1,Inhibitor
CBNumber: CB42750677
Molecular Formula: C14H10Cl4N2O
Formula Weight: 364.05
MOL File: 219315-22-7.mol

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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

WGK Germany: 3
HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0629
Product name: Mitochondrial Fusion Promoter M1
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: 475859
Product name: Mitochondrial Fusion Promoter, M1
Packaging: 25mg
Price: $166
Updated: 2022/05/15

Tocris

Product number: 6898
Product name: Mitochondrial Fusion Promoter, M1
Purity: ≥98%(HPLC)
Packaging: 25
Price: $102
Updated: 2021/12/16

ChemScene

Product number: CS-0041573
Product name: Mitochondrial Fusion Promoter, M1
Purity: 99.87%
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0041573
Product name: Mitochondrial Fusion Promoter, M1
Purity: 99.87%
Packaging: 50mg
Price: $150
Updated: 2021/12/16

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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Chemical Properties,Usage,Production

Description

M-1 (219315-22-7) enhances mitochondrial fusion without interfering with endoplasmic reticulum (ER) and lysosome morphology.1 M-1 protects cells from mitochondrial fragmentation-associated cell death.2 Promotion of mitochondrial fusion has protective effects in rotenone-induced neurotoxicity.3 Cell permeable.

Uses

Mitochondrial Fusion Promoter M1 has been used as a fusion promoter:

to study its effects on peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α expression in breast cancer cells
to study the link between nucleoside diphosphate kinase 3 (NME3)-regulated mitochondrial fluctuations and stability of genome in NME3 knockdown cells
to study its effects on mitochondrial fusion in neuronal cells

General Description

A cell-permeable phenylhydrazone compound that restores mitochondrial tubular network formation from the fragmented mitochondria seen in MEF lacking either one of the two outer mitochondrial membrane (OMM) mitofusins (EC₅₀ = 5.3 and 4.42 μM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or MPP+-treated SH-SY5Y cells (5 μM 24 h), while displaying no effect on ER or lysosome morphology in Mfn1 knockout MEF. The effect of M1 is limited to enhancing weakened mitochondrial fusion machinery and M1 cannot by itself rebuild interconnected tubular mitochondria in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5 μM 24 h) is reported to boost the downregulated ATP5A and ATP5B protein level in either Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin (Cat. No. 495455) at 5 μM is shown to completely offset the mitochondrial fusion effect by 5 μM M1 in Mfn1 knockout MEF. Both M1 and Z-VAD-FMK (Cat. No. 219007) are shown to protect SH-SY5Y against MPP⁺-induced neuronal toxicity and additive protection can be achieved via a combined treatment (62%, 73%, 77%, and 89% survival rate, respectively, with DMSO, 5 μM M1, 1 μM Z-VAD-FMK, and combined treatment). Comparing to mdivi-1 (Cat. No. 475856), M1 exerts its effect via promoting fusion rather than inhibiting fission or division.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

References

Andreaux et al. (2013), Pharmacological approaches to restore mitochondrial function; Nature Rev. Drug Disc., 12 465 Yang et al. (2015), Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA; Cell Mol. Life Sci., 72 2585 Peng et al. (2017), The interaction of mitochondrial Biogenesis and Fission/Fusion Mediated b PGC-1a Regulates Rotenone-Induced Dopaminergic Neurotoxicity; Neurobiol., 54 3783

1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Suppliers

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Sigma-Aldrich

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219315-22-7, 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazoneRelated Search:

VALINOMYCIN Salinomycin Auranofin

(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol

1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone

Mitochondrial Fusion Promoter M1

Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem

Ethanone, 1-(5-chloro-2-hydroxyphenyl)-, 2-(2,4,6-trichlorophenyl)hydrazone

Mitochondrial Fusion Promoter M1 >=95% (HPLC)

Mitochondrial Metabolism,ischemia,cardiac,inhibit,brain,damage,injury,reperfusion,Mitochondrial fusion promoter M 1,Mitochondrial fusion promoter M-1,Mitochondrial fusion promoter M1,Inhibitor

1-(5-Chloro-2-hydroxyphenyl)ethanone (2,4,6-trichlorophenyl)hydrazone

219315-22-7