Salinomycin
Chemical Properties Uses production method- Product Name
- Salinomycin
- CAS No.
- 55721-31-8
- Chemical Name
- Salinomycin
- Synonyms
- Salinomycin;Salinomycin Na;Salinomycin-Natrium;Glycerol Impurity 109;Salomycin sodium salt;Salinomycin sodium premix;Salinomycin 1-sodium salt;Salinomycin, monosodium salt;Salinomycin, sodiumsalt (1:1);Salinomycin sodium (Procoxacin)
- CBNumber
- CB6161783
- Molecular Formula
- C42H71NaO12
- Formula Weight
- 791
- MOL File
- 55721-31-8.mol
Salinomycin Property
- Melting point:
- 140-142°
- alpha
- D25 -37° (c = 1 in ethanol)
- storage temp.
- APPROX 4°C
- solubility
- Soluble in DMSO.
- color
- White
- Merck
- 13,8415
- BRN
- 4901827
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13579
- Product name
- Salinomycin (sodium salt)
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 13579
- Product name
- Salinomycin (sodium salt)
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- 13579
- Product name
- Salinomycin (sodium salt)
- Purity
- ≥90%
- Packaging
- 50mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 13579
- Product name
- Salinomycin (sodium salt)
- Purity
- ≥90%
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- S088805
- Product name
- SalinomycinSodiumSalt
- Packaging
- 250mg
- Price
- $870
- Updated
- 2021/12/16
Salinomycin Chemical Properties,Usage,Production
Chemical Properties
White or light yellow crystalline powder, slight specific smell, melting point 140-142 ℃. Soluble in acetone, chloroform, benzene, ethyl acetate, diethyl ether and methanol, almost insoluble in water. Rats by oral LD5070-100mg/kg, mice orally LD5050mg/kg, chicken LD50150mg/kg.
Uses
Salinomycin is safe and effective coccidiostat,which has inhibitory effect on most Gram-positive bacteria ,it also has effect on chicken coccidiosis, soft Ehrlich, Ehrlich poison, giant Ehrlich, Ehrlich and heap-shaped ball Harrington insects. It can be used for chicken feed, the amount is 50-60g/t,it should be stopped during laying period, the period is 5 days. Equine animals are hanged, it causes death after use; and it is banned using it with tiamulin, oleandomycin simultaneously.
The above information is edited by the chemicalbook of Tian Ye.
production method
It is produced by fermentation of white Streptomyces (Streptomyces albus).
Description
Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5
Chemical Properties
Brown Solid
Uses
Salinomycin is an ionophore agent.
Uses
Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.
References
1) Gupta?et al. (2009),?Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell,?138?645 2) Manago?et al. (2015),?Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis.,?6?e1930 3) Fu?et al. (2016),?Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway;?Oncol. Rep.,?35?912 4)?Kim?et al.?(2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin;?Mol. Med. Rep.,?12(2)?1898 5) Mai et al. (2017)?Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem.,?9?1025
Salinomycin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Salinomycin manufacturers
- Product
- Salinomycin sodium salt 55721-31-8
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-25
- Product
- Salinomycin Sodium 55721-31-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-04-10
- Product
- Salinomycin Sodium 55721-31-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-04-10