ChemicalBook > CAS DataBase List > (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT

(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT

Product Name
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT
CAS No.
13613-65-5
Chemical Name
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT
Synonyms
BHB Na;KTX 0101;[R]-3-Hydroxbutanoic acid;SODIUM D-3-HYDROXYBUTYRATE;SodiuM D-β-Hydroxybutyrate;sodiuM(R)-3-hydroxybutanoate;(R)-3-hydroxybutyrate sodium;Sodium (R)-3-hydroxybutyrate;optical purity ee: 99% (GLC);D-(-)-beta-Hydroxybutyricacid
CBNumber
CB7172553
Molecular Formula
C4H9NaO3
Formula Weight
128.1
MOL File
13613-65-5.mol
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(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT Property

Melting point:
149-155 °C(lit.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
optical activity
[α]22/D 14°, c = 10 in H2O
Water Solubility 
Water: 100 mg/mL (793.08 mM)
BRN 
6118796
Stability:
Hygroscopic
InChI
InChI=1/C4H8O3.Na.H/c1-3(5)2-4(6)7;;/h3,5H,2H2,1H3,(H,6,7);;/t3-;;/s3
InChIKey
DIKSWKJUJFMKBT-LPWWCTNINA-N
SMILES
C(C(=O)O)[C@H](O)C.[NaH] |&1:4,r|
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
3-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
298360
Product name
(R)-(?)-3-Hydroxybutyric acid sodium salt
Purity
optical purity ee: 99% (GLC)
Packaging
1g
Price
$169
Updated
2025/07/31
TRC
Product number
H833025
Product name
(R)-(?)-3-Hydroxybutyric acid sodium salt
Packaging
5g
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-W016567
Product name
(R)-3-Hydroxybutanoicacid(sodium)
Purity
≥97.0%
Packaging
1g
Price
$38
Updated
2021/12/16
AK Scientific
Product number
J96005
Product name
Sodium(R)-3-hydroxybutanoate
Packaging
1g
Price
$40
Updated
2021/12/16
ChemScene
Product number
CS-W016567
Product name
(R)-3-Hydroxybutanoicacid(sodium)
Purity
≥97.0%
Packaging
5g
Price
$61
Updated
2021/12/16
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(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

mp 165-167°C

Uses

chiral synthon

Uses

(R)-(-)-3-Hydroxybutyric acid sodium salt reacts with crown ether to form a supramolecular complex, which can catalyze the regioselective ring-opening polymerization of (S)-butyrolactone to form (R)-3-hydroxybutyrate oligomers (OHBs).

Uses

Optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems.

Synthesis

3976-69-0

13613-65-5

In a 500 mL three-necked flask, methyl (R)-3-hydroxybutyrate (76.0 g) made from Example 1 was added, followed by 300 mL of water. The reaction temperature was controlled to be below 30 °C, and sodium hydroxide (25.8 g) was added slowly in batches over a period of 3 hours. After addition, maintain the temperature no higher than 10°C and continue to stir the reaction for 3 hours until the reaction is complete. Add 0.3 g of activated carbon and filter after continuous stirring for 0.5 hours. The filtrate was concentrated to 100 mL, at which time a large amount of solid precipitated. Crystallization was stirred at room temperature for 1 hour, centrifuged and dried in vacuum to obtain 68.9 g of (R)-(-)-3-hydroxybutyric acid sodium salt as a white solid with a yield of 85.0% and an ee value of 91.5%.

References

[1] Patent: CN107162893, 2017, A. Location in patent: Paragraph 0042; 0043

(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT Suppliers

Hefei Qianhang Pharmaceutical Technology Co., Ltd.
Tel
13346199520
Email
1356223173@qq.com
Country
China
ProdList
61
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58
Ningbo biermann pharmaceutical technology co., LTD
Tel
0571-82572971 13736400971
Fax
0574-87703432
Email
bichem.sales01@bichem.cn
Country
China
ProdList
47
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58
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd
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13970866816
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info@rochipharma.com
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China
ProdList
305
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SHANGHAI KANGXIN CHEMICAL CO.,LTD
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02160717229 19821090907
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shkx@shkangxin.com.cn
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China
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Shanghai Yiyan Biotechnology Co. , Ltd.
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021-69985186 13611928337
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3427709316@qq.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Energy Chemical
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021-58436166
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China
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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42934
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
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China
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View Lastest Price from (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
(R)-3-Hydroxybutanoic acid sodium 13613-65-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT 13613-65-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Baoji Guokang Healthchem Co., Ltd.
Product
R)-(-)-3-Hydroxybutyric Acid, Sodium Salt 13613-65-5
Price
US $130.00/KG
Min. Order
5Kg/Bag
Purity
99%
Supply Ability
1000KG
Release date
2021-06-04

13613-65-5, (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALTRelated Search:


  • Sodium -3-Hydroxybutyrate-2,4-13C2
  • [R]-3-Hydroxbutanoic acid
  • sodiuM(R)-3-hydroxybutanoate
  • SODIUM D-3-HYDROXYBUTYRATE
  • sodiuM (3R)-3-hydroxybutanoate
  • (3R)-3-Hydroxybutanoic Acid SodiuM Salt
  • (R)-3-Hydroxybutanoic Acid MonosodiuM Salt
  • (R)-3-Hydroxybutanoic Acid Sodium Salt
  • Natural (R)-3-Hydroxybutanoic Acid Sodium Salt
  • (R)-(-)-3-Hydroxybutyric acid sodiuM salt optical purity ee: 99% (GLC)
  • [R]-3-HYDROXBUTANOIC ACID SODIUM SALT
  • (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT
  • (R)-3-HYDROXYBUTYRIC ACID SODIUM SALT
  • (R)-(-)-SODIUM- 3-HYDROXYBUTYRATE
  • (R)-(-)-3-HydroxyButyric Acid Sodium
  • (R)-3-hydroxybutyrate sodium
  • D-(-)-3-Hydroxybutyric Acid MonosodiuM Salt
  • KTX 0101
  • SodiuM D-β-Hydroxybutyrate
  • D-(-)-BETA-HYDROXYBUTYRIC ACID SODIUM SALT
  • (R)-()-3-Hydroxyisobutyric acid Sodium salt
  • (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SA
  • Sodium (R)-3-hydroxybutyrate
  • D-(-)-beta-Hydroxybutyricacid
  • (R)-(-)-3-Hydroxybutyric acid sodium saL
  • (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT Basic information
  • (R)-3-Hydroxybutanoic acid sodium
  • (R)-3-Hydroxybutyric Acid,Sadium Salt
  • optical purity ee: 99% (GLC)
  • (R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid)
  • D-3-Hydroxybutyrate sodium salt
  • BHB Na
  • Sodium D-Beta Hydroxybutyrate(D-BHB Na)
  • (<i>R</i>)-(?)-3-Hydroxybutyric acid sodium salt
  • D-3-HYDROXYBUTYRIC SODIUM SALT
  • 13613-65-5
  • C4H7O3Na
  • Organic Building Blocks
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Carboxylic Acid Salts
  • Aliphatics
  • Chiral Reagents
  • Chiral Alcohols