N-(2-Aminophenyl)pyrazine-2-carboxamide

ChemicalBook > CAS DataBase List > N-(2-Aminophenyl)pyrazine-2-carboxamide

N-(2-Aminophenyl)pyrazine-2-carboxamide

Product Name: N-(2-Aminophenyl)pyrazine-2-carboxamide
CAS No.: 926259-99-6
Chemical Name: N-(2-Aminophenyl)pyrazine-2-carboxamide
Synonyms: BG45;CS-2040;BG45;BG 45;45, HDAC3 Inhibitor;BG45, HDAC3 Inhibitor;B 45, HDAC3 Inhibitor;N-(2-Aminophenyl)pyrazine-2-carboxamide;n-(2-aminophenyl)-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, N-(2-aminophenyl)-;PYRAZINE-2-CARBOXYLIC ACID-(2-AMINO-ANILIDE)
CBNumber: CB42750697
Molecular Formula: C11H10N4O
Formula Weight: 214.22
MOL File: 926259-99-6.mol

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N-(2-Aminophenyl)pyrazine-2-carboxamide Property

Melting point:: 160-163°C
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 36/37/39
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0867
Product name: BG45
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $108
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML0867
Product name: BG45
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $424
Updated: 2022/05/15

Cayman Chemical

Product number: 16918
Product name: BG45
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 16918
Product name: BG45
Purity: ≥95%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 16918
Product name: BG45
Purity: ≥95%
Packaging: 25mg
Price: $356
Updated: 2024/03/01

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N-(2-Aminophenyl)pyrazine-2-carboxamide Chemical Properties,Usage,Production

Description

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC₅₀ = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC₅₀s = 2, 2.2, and >20 μM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.

Uses

BG45 acts as an HDAC class I inhibitor with selectvity for HDAC3. HDACs represent novel targets for anti-tumer drugs treating various cancers including multiple myeloma cancer.

Definition

ChEBI: N-(2-aminophenyl)-2-pyrazinecarboxamide is an aromatic amide.

in vitro

bg45 is reported as an hdac class i inhibitor with selectivity for hdac3 over hdac1, 2. consistent with hdac3 knockdown data, bg45 significantly inhibited mm cell growth dose-dependently. importantly, bg45 also triggered a potent growth inhibitory effect against patient-derived mm cells, without affecting normal donor pbmcs [1].

in vivo

bg45 significantly inhibited mm tumor growth in a dose-dependent fashion. for example, significant differences were observed in control versus bg45 15 mg/kg, control versus bg45 50 mg/kg, and bg45 15 mg/kg versus bg45 50 mg/kg at day 22. moreover, bg45 50 mg/kg in combination with bortezomib enhanced either single agent activity further. these results confirmed that bg45 triggers in vivo anti-mm activities [1].

IC 50

289 nm

References

[1] minami j, suzuki r, mazitschek r, gorgun g, ghosh b, cirstea d, hu y, mimura n, ohguchi h, cottini f, jakubikova j, munshi nc, haggarty sj, richardson pg, hideshima t, anderson kc. histone deacetylase 3 as a novel therapeutic target in multiple myeloma. leukemia. 2014 mar;28(3):680-9.

N-(2-Aminophenyl)pyrazine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(2-Aminophenyl)pyrazine-2-carboxamide manufacturers

Career Henan Chemical Co

Product: N-(2-Aminophenyl)pyrazine-2-carboxamide 926259-99-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

926259-99-6, N-(2-Aminophenyl)pyrazine-2-carboxamideRelated Search:

BG45, 98%, a HDAC class I inhibitor with selectivity for HDAC3

BG45, HDAC3 Inhibitor

BG45

N-(2-Aminophenyl)pyrazine-2-carboxamide

PYRAZINE-2-CARBOXYLIC ACID-(2-AMINO-ANILIDE)

BG45;BG 45

CS-2040

45, HDAC3 Inhibitor

2-Pyrazinecarboxamide, N-(2-aminophenyl)-

Inhibitor,inhibit,BG45,HDAC,Histone deacetylases,BG-45,BG 45,Apoptosis

n-(2-aminophenyl)-2-pyrazinecarboxamide

B 45, HDAC3 Inhibitor

926259-99-6

Inhibitors