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N-(2-Aminophenyl)pyrazine-2-carboxamide

Product Name
N-(2-Aminophenyl)pyrazine-2-carboxamide
CAS No.
926259-99-6
Chemical Name
N-(2-Aminophenyl)pyrazine-2-carboxamide
Synonyms
BG45;CS-2040;BG45;BG 45;45, HDAC3 Inhibitor;BG45, HDAC3 Inhibitor;B 45, HDAC3 Inhibitor;N-(2-Aminophenyl)pyrazine-2-carboxamide;n-(2-aminophenyl)-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, N-(2-aminophenyl)-;PYRAZINE-2-CARBOXYLIC ACID-(2-AMINO-ANILIDE)
CBNumber
CB42750697
Molecular Formula
C11H10N4O
Formula Weight
214.22
MOL File
926259-99-6.mol
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N-(2-Aminophenyl)pyrazine-2-carboxamide Property

Melting point:
160-163°C
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
36/37/39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0867
Product name
BG45
Purity
≥98% (HPLC)
Packaging
5mg
Price
$108
Updated
2022/05/15
Sigma-Aldrich
Product number
SML0867
Product name
BG45
Purity
≥98% (HPLC)
Packaging
25mg
Price
$424
Updated
2022/05/15
Cayman Chemical
Product number
16918
Product name
BG45
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
16918
Product name
BG45
Purity
≥95%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
16918
Product name
BG45
Purity
≥95%
Packaging
25mg
Price
$356
Updated
2024/03/01
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N-(2-Aminophenyl)pyrazine-2-carboxamide Chemical Properties,Usage,Production

Description

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.

Uses

BG45 acts as an HDAC class I inhibitor with selectvity for HDAC3. HDACs represent novel targets for anti-tumer drugs treating various cancers including multiple myeloma cancer.

Definition

ChEBI: N-(2-aminophenyl)-2-pyrazinecarboxamide is an aromatic amide.

in vitro

bg45 is reported as an hdac class i inhibitor with selectivity for hdac3 over hdac1, 2. consistent with hdac3 knockdown data, bg45 significantly inhibited mm cell growth dose-dependently. importantly, bg45 also triggered a potent growth inhibitory effect against patient-derived mm cells, without affecting normal donor pbmcs [1].

in vivo

bg45 significantly inhibited mm tumor growth in a dose-dependent fashion. for example, significant differences were observed in control versus bg45 15 mg/kg, control versus bg45 50 mg/kg, and bg45 15 mg/kg versus bg45 50 mg/kg at day 22. moreover, bg45 50 mg/kg in combination with bortezomib enhanced either single agent activity further. these results confirmed that bg45 triggers in vivo anti-mm activities [1].

IC 50

289 nm

References

[1] minami j, suzuki r, mazitschek r, gorgun g, ghosh b, cirstea d, hu y, mimura n, ohguchi h, cottini f, jakubikova j, munshi nc, haggarty sj, richardson pg, hideshima t, anderson kc. histone deacetylase 3 as a novel therapeutic target in multiple myeloma. leukemia. 2014 mar;28(3):680-9.

N-(2-Aminophenyl)pyrazine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Aminophenyl)pyrazine-2-carboxamide Suppliers

China 59 India 1 United Kingdom 1 United States 11 Global 72
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from N-(2-Aminophenyl)pyrazine-2-carboxamide manufacturers

Career Henan Chemical Co
Product
N-(2-Aminophenyl)pyrazine-2-carboxamide 926259-99-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

926259-99-6, N-(2-Aminophenyl)pyrazine-2-carboxamideRelated Search:


  • BG45, 98%, a HDAC class I inhibitor with selectivity for HDAC3
  • BG45, HDAC3 Inhibitor
  • BG45
  • N-(2-Aminophenyl)pyrazine-2-carboxamide
  • PYRAZINE-2-CARBOXYLIC ACID-(2-AMINO-ANILIDE)
  • BG45;BG 45
  • CS-2040
  • 45, HDAC3 Inhibitor
  • 2-Pyrazinecarboxamide, N-(2-aminophenyl)-
  • Inhibitor,inhibit,BG45,HDAC,Histone deacetylases,BG-45,BG 45,Apoptosis
  • n-(2-aminophenyl)-2-pyrazinecarboxamide
  • B 45, HDAC3 Inhibitor
  • 926259-99-6
  • Inhibitors