ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
- Product Name
- ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
- CAS No.
- 11002-13-4
- Chemical Name
- ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
- Synonyms
- DRVYIHPFHLVIHN;ANGIOTENSINOGEN;RENIN SUBSTRATE;hypertensinogen;ANGIOTENSINOGEN 1-14;RENIN SUBSTRATE, HUMAN;PREANGIOTENSINOGEN 1-14;HUMAN PREANGIOTENSINOGEN 1-14;ANGIOTENSINOGEN FRAGMENT 1-14;ANGIOTENSINOGEN (1-14) (HUMAN)
- CBNumber
- CB4277703
- Molecular Formula
- C83H122N24O19
- Formula Weight
- 1760.01
- MOL File
- 11002-13-4.mol
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN Property
- storage temp.
- −20°C
- form
- lyophilized powder
- color
- white
- Water Solubility
- water: soluble
Safety
- Hazard Codes
- B
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A2562
- Product name
- Angiotensinogen from human plasma
- Purity
- ≥80% (SDS-PAGE), lyophilized powder
- Packaging
- 0.1mg
- Price
- $304.8
- Updated
- 2024/03/01
- Product number
- 153512
- Product name
- Angiotensinogen
- Packaging
- 10ug
- Price
- $327
- Updated
- 2021/12/16
- Product number
- 153511
- Product name
- Angiotensinogen
- Packaging
- 10ug
- Price
- $327
- Updated
- 2021/12/16
- Product number
- 153510
- Product name
- Angiotensinogen
- Packaging
- 10ug
- Price
- $358
- Updated
- 2021/12/16
- Product number
- 153509
- Product name
- Angiotensinogen
- Packaging
- 10ug
- Price
- $358
- Updated
- 2021/12/16
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN Chemical Properties,Usage,Production
Uses
Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.
Biological Functions
Human plasma contains a glycoprotein called angiotensinogen, which serves as the only known substrate for renin. Angiotensinogen must undergo proteolysis before active portions of the protein are sufficiently unmasked to exert biological effects. Angiotensinogen is synthesized in many organs, including the liver, brain, kidney, and fat. Its gene transcription and plasma concentrations increase following treatment with adrenocorticotropic hormone (ACTH), glucocorticoids, thyroid hormone, and estrogens, as well as during pregnancy and inflammation and after nephrectomy. Angiotensinogen also has been found in large quantities in cerebrospinal and amniotic fluid. Mutations in the angiotensinogen gene have been reported to be linked to human hypertension.
Biological Activity
Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system th at regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases. Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN Preparation Products And Raw materials
Raw materials
Preparation Products
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN Suppliers
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