ASP-ARG-VAL-TYR-ILE-HIS-PRO
- Product Name
- ASP-ARG-VAL-TYR-ILE-HIS-PRO
- CAS No.
- 51833-78-4
- Chemical Name
- ASP-ARG-VAL-TYR-ILE-HIS-PRO
- Synonyms
- A779;DRVYIHP;Ang-(1-7);Merotocin;Talfirastide;DRVYIH{D-Ala};H2N-DRVYIHP-OH;angiotension 1-7;angiotensinii(1-7;ANGIOTENSIN (1-7)
- CBNumber
- CB6196808
- Molecular Formula
- C41H62N12O11
- Formula Weight
- 899
- MOL File
- 51833-78-4.mol
ASP-ARG-VAL-TYR-ILE-HIS-PRO Property
- Melting point:
- >202°C (dec.)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
- form
- powder
- pka
- 3.29±0.20(Predicted)
- color
- White to Off-White
- Water Solubility
- Soluble to 1 mg/ml in water
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A9202
- Product name
- Angiotensin Fragment 1-7 acetate salt hydrate
- Purity
- ≥90% (HPLC), powder
- Packaging
- 1mg
- Price
- $75.1
- Updated
- 2024/03/01
- Product number
- A9202
- Product name
- Angiotensin Fragment 1-7 acetate salt hydrate
- Purity
- ≥90% (HPLC), powder
- Packaging
- 5mg
- Price
- $281
- Updated
- 2024/03/01
- Product number
- 1562
- Product name
- Angiotensin(1-7)
- Packaging
- 1
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 5937
- Product name
- A779
- Packaging
- 5
- Price
- $86
- Updated
- 2021/12/16
- Product number
- A637945
- Product name
- Angiotensin(1-7)xTFAsalt
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
ASP-ARG-VAL-TYR-ILE-HIS-PRO Chemical Properties,Usage,Production
Uses
Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.
Definition
ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.
Biological Activity
ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems.
Biochem/physiol Actions
Angiotensin I metabolite that is an AT2 receptor agonist.
storage
Store at -20°C
References
1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)
ASP-ARG-VAL-TYR-ILE-HIS-PRO Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ASP-ARG-VAL-TYR-ILE-HIS-PRO manufacturers
- Product
- ASP-ARG-VAL-TYR-ILE-HIS-PRO 51833-78-4
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-27
- Product
- ASP-ARG-VAL-TYR-ILE-HIS-PRO 51833-78-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17