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ASP-ARG-VAL-TYR-ILE-HIS-PRO

Product Name
ASP-ARG-VAL-TYR-ILE-HIS-PRO
CAS No.
51833-78-4
Chemical Name
ASP-ARG-VAL-TYR-ILE-HIS-PRO
Synonyms
A779;DRVYIHP;Ang-(1-7);Merotocin;Talfirastide;DRVYIH{D-Ala};H2N-DRVYIHP-OH;angiotension 1-7;angiotensinii(1-7;ANGIOTENSIN (1-7)
CBNumber
CB6196808
Molecular Formula
C41H62N12O11
Formula Weight
899
MOL File
51833-78-4.mol
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ASP-ARG-VAL-TYR-ILE-HIS-PRO Property

Melting point:
>202°C (dec.)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form 
powder
pka
3.29±0.20(Predicted)
color 
White to Off-White
Water Solubility 
Soluble to 1 mg/ml in water
InChIKey
PVHLMTREZMEJCG-UHFFFAOYSA-N
SMILES
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O
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Safety

WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9202
Product name
Angiotensin Fragment 1-7 acetate salt hydrate
Purity
≥90% (HPLC), powder
Packaging
1mg
Price
$74.95
Updated
2025/07/31
Sigma-Aldrich
Product number
A9202
Product name
Angiotensin Fragment 1-7 acetate salt hydrate
Purity
≥90% (HPLC), powder
Packaging
5mg
Price
$290
Updated
2025/07/31
Tocris
Product number
1562
Product name
Angiotensin(1-7)
Packaging
1
Price
$75
Updated
2021/12/16
Tocris
Product number
5937
Product name
A779
Packaging
5
Price
$86
Updated
2021/12/16
TRC
Product number
A637945
Product name
Angiotensin(1-7)xTFAsalt
Packaging
10mg
Price
$65
Updated
2021/12/16
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ASP-ARG-VAL-TYR-ILE-HIS-PRO Chemical Properties,Usage,Production

Uses

Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.

Definition

ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.

Biological Activity

ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems.

Biochem/physiol Actions

Angiotensin I metabolite that is an AT2 receptor agonist.

storage

Store at -20°C

References

1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)

ASP-ARG-VAL-TYR-ILE-HIS-PRO Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP-ARG-VAL-TYR-ILE-HIS-PRO Suppliers

China 163 France 1 Germany 4 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 28 Global 201
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View Lastest Price from ASP-ARG-VAL-TYR-ILE-HIS-PRO manufacturers

Henan Fengda Chemical Co., Ltd
Product
ASP-ARG-VAL-TYR-ILE-HIS-PRO 51833-78-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-27
Career Henan Chemical Co
Product
ASP-ARG-VAL-TYR-ILE-HIS-PRO 51833-78-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-17

51833-78-4, ASP-ARG-VAL-TYR-ILE-HIS-PRORelated Search:

ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT ANGIOTENSIN II, HUMAN Blood Agar plate HEMOCYANIN, KEYHOLE LIMPET EC 3.4.15.1 NA Serum digestion powder ANGIOTENSIN I, HUMAN H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH,ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER ASP-ARG-VAL-TYR-ILE-HIS-PRO Angiotensin ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER,H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH ASP-ARG-VAL-TYR-ILE-HIS-PRO-LEU-HIS-LEU-LEU-TYR-TYR-SER ASP-ARG-VAL-TYR-ILE-HIS-PRO-ALA ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS,H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-OH ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH,ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN BIOTINYL-ASP-ARG-VAL-TYR-ILE-HIS-PRO-OH H-GLY-GLY-HIS-GLY-OH

  • angiotensinii(1-7
  • angiotensin fragment 1-7 human acetate
  • A779
  • H2N-DRVYIHP-OH
  • H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-OH
  • (DES-PHE8) ANGIOTENSIN II
  • DRVYIHP
  • ANGIOTENSIN (HUMAN, 1-7) (CANINE, RAT)
  • ANGIOTENSIN (1-7)
  • ANGIOTENSIN CANINE RAT
  • ANGIOTENSIN 1/2 (1-7)
  • ANGIOTENSIN I/II (1-7)
  • ANGIOTENSIN I/II (1-7), HUMAN
  • ANGIOTENSIN II FRAGMENT 1-7
  • ASP-ARG-VAL-TYR-ILE-HIS-PRO
  • L-ASP-ARG-VAL-TYR-ILE-HIS-PRO
  • Angiotensin Fragment1-7 hydrate acetate salt
  • angiotensin fragment 1-7 acetate hydrate
  • Angiotensin I/II (1-7) trifluoroacetate salt H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt
  • DRVYIH{D-Ala}
  • Angiotensin 1-7, >98%
  • Angiotensin 1-7 (Angiotensin (1-7)
  • Angiotensin I(1-7)【rat】
  • Angiotensin II(1-7)【rat】
  • Aspartyl-argininyl-valinyl-tyrosinyl-isoleucinyl-histidinyl-proline
  • Angiotensin I/II (1-7) Asp-Arg-Val-Tyr-Ile-His-Pro
  • Angiotensin ii (1-7) heptapeptide
  • Angiotensin ii, 5-L-isoleucine-8-de-L-phenylalanine-
  • Angiotensin Fragment1-7 acetate salt hydrate
  • Ang-(1-7)
  • Angiotensin I/II (1-7)|A779|Angiotensin,Canine,Rat
  • Merotocin
  • Angiotensin (1-7) xTFA salt
  • 1-7-Angiotensin II, 5-L-isoleucine-
  • angiotension 1-7
  • Angiotensin (1-7) , Canine, Rat
  • Talfirastide
  • Talfirastide Angiotensin (1-7)
  • Angiotensin fragment 1-7 acetate salt
  • Angiotensin (1-7) , Canine, Rat、Angiotensin I/II (1-7)
  • 51833-78-4
  • C41H62N12O11
  • Peptides
  • Amino Acids and Peptides
  • Angiotensins
  • Biochemicals and Reagents
  • BioChemical
  • API
  • Cardiovescular
  • AngiotensinsPeptides for Cell Biology
  • Angiotensins
  • Neuropeptides
  • Peptides for Cell Biology
  • Angiotensin
  • Peptide