SR 202
Description- Product Name
- SR 202
- CAS No.
- 76541-72-5
- Chemical Name
- SR 202
- Synonyms
- SR 202;MIFOBATE;Clenicor;claniclor;SR-202 >=98% (HPLC), crystalline;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate;DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE;(4-Chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate;[(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
- CBNumber
- CB4285085
- Molecular Formula
- C11H17ClO7P2
- Formula Weight
- 358.65
- MOL File
- 76541-72-5.mol
SR 202 Property
- Boiling point:
- 436.6±45.0 °C(Predicted)
- Density
- 1.355±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: 5 mg/mL
- form
- crystalline
- color
- white
- Water Solubility
- Soluble to 100 mM in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 2
- RTECS
- TB8817000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21846
- Product name
- SR 202
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 21846
- Product name
- SR 202
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 2022
- Product name
- SR202
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 2022
- Product name
- SR202
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $616
- Updated
- 2021/12/16
- Product number
- 256741
- Product name
- SR 202
- Packaging
- 10mg
- Price
- $389
- Updated
- 2021/12/16
SR 202 Chemical Properties,Usage,Production
Description
SR 202 is an effective and specific PPARγ antagonist that selectively inhibits the transcriptional activity of PPARγ induced by TZD (IC50=140 μM). Sr-202 does not affect basal or ligand stimulated transcriptional activity of PPARα, PPARβ, or FXR. It has anti-obesity and anti-diabetes effects.
Uses
Anti-atherosclerotic.
Uses
SR 202 is a noniodinated, potential lipid-altering agent and an inhibitor of the peripheral conversion of T4 to T3 associated with thyroid hormone metabolism.
Definition
ChEBI: Phosphoric acid [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl ester is a trialkyl phosphate.
brand name
Clenicor (Symphar S.A.,Switzerland).
Biological Activity
Selective PPAR γ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPAR γ transcriptional activity (IC 50 = 140 μ M) without affecting ligand-stimulated PPAR α , PPAR β or FXR transcriptional activity. Inhibits PPAR γ -dependent adipocyte differentiation and growth in vitro and in vivo . Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo .
in vitro
sr-202 is a specific antagonist of ppar, which shows selectivity both among the ppar family members and other nuclear receptors. sr-202 also inhibits ppar-dependent differentiation of adipocytes. in cell culture, sr-202 efficiently antagonizes hormone- and tzd induced adipocyte differentiation [1].
in vivo
. decreasing ppar activity by treatment with sr-202 leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance. treatment with sr-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice [1]. when wild-type mice are fed a high-fat diet, the plasma levels of tnf-α are raised, and sr-202 treatment protects against this rise [2]..
IC 50
140 μm for attenuation of troglitazone-induced peroxisome proliferator-activated receptor gamma (ppar) transcriptional activity [1]
storage
Desiccate at RT
References
[1] rieusset j, touri f, michalik l, escher p, desvergne b, niesor e, wahli w. a new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. mol endocrinol. 2002 nov;16(11):2628-44.
[2] doggrell s. do peroxisome proliferation receptor-gamma antagonists have clinical potential as combined antiobesity and antidiabetic drugs expert opin investig drugs. 2003 apr;12(4):713-6.
SR 202 Preparation Products And Raw materials
Raw materials
Preparation Products
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