2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL
- Product Name
- 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL
- CAS No.
- 5521-38-0
- Chemical Name
- 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL
- Synonyms
- 2-(4-(4-Nitrophenyl);1-Piperazineethanol, 4-(4-nitrophenyl)-;2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL;2-[4-(4-NITROPHENYL)PIPERAZIN-1-YL]ETHANOL;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol,97%;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol, 97%
- CBNumber
- CB4286062
- Molecular Formula
- C12H17N3O3
- Formula Weight
- 251.28
- MOL File
- 5521-38-0.mol
2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL Property
- Melting point:
- 97-99°C
- Boiling point:
- 445.6±45.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.96±0.10(Predicted)
- form
- Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- N545298
- Product name
- 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N545298
- Product name
- 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 044509
- Product name
- 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
- Purity
- >95%
- Packaging
- 500mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 044509
- Product name
- 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
- Purity
- >95%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 044509
- Product name
- 2-[4-(4-Nitrophenyl)piperazino]-1-ethanol
- Purity
- >95%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL Chemical Properties,Usage,Production
Synthesis
103-76-4
350-46-9
5521-38-0
To a stirred suspension of anhydrous dimethyl sulfoxide (10 mL) of 1-fluoro-4-nitrobenzene (2 g, 14.17 mmol) and potassium carbonate (3.92 g, 28.3 mmol) was slowly added 2-(piperazin-1-yl)ethanol (2.089 mL, 17.01 mmol). The reaction mixture was heated and stirred at 80°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into water (100 mL) and extracted with ethyl acetate (30 mL). The aqueous layer was separated and a second extraction was performed with ethyl acetate (2 x 30 mL). All organic phases were combined and concentrated under reduced pressure to remove the solvent. The concentrated residue was ground in water (100 mL) to precipitate a solid. The solid product was collected by vacuum filtration and dried under vacuum with a stream of nitrogen for 16 h to afford the target compound 2-[4-(4-nitrophenyl)piperazine]-1-ethanol (3.45 g, 97% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.11 (d, 2H), 6.82 (d, 2H), 3.68 (t, 2H), 3.44 (t, 4H), 2.67 (t, 4H), 2.62 (t, 2H), 2.55 (br s, 1H).Results of the analysis by LCMS (Method C): retention time (RT) = 0.45 min, m/z = 252 [M + H]+.
References
[1] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 236
[2] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0322
[3] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 112-113
[4] Patent: WO2016/138527, 2016, A1. Location in patent: Paragraph 00212
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387
2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL Preparation Products And Raw materials
Raw materials
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