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BOC-L-Phenylglycinol

Product Name
BOC-L-Phenylglycinol
CAS No.
117049-14-6
Chemical Name
BOC-L-Phenylglycinol
Synonyms
(S)-N-(TERT-BUTOXYCARBONYL)-2-PHENYLGLYCINOL;tert-butyl (S)-(2-hydroxy-1-phenylethyl)carbamate;BOC-PHG-OL;Boc-L-Phg-OL;CAS:117049-14-6;Boc-L-phenyglycol;BOC-PHENYLGLYCINOL;BOC-L-PHENYLGLYCINOL;TBOC-L-PHENYLGLYCINOL;Asciminib Impurity 19
CBNumber
CB4287458
Molecular Formula
C13H19NO3
Formula Weight
237.29
MOL File
117049-14-6.mol
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BOC-L-Phenylglycinol Property

Melting point:
136-139 °C(lit.)
alpha 
+37°(19℃, c=1, CHCl3)
Boiling point:
382.4±35.0 °C(Predicted)
Density 
1.101±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
11.55±0.46(Predicted)
color 
White to Orange to Green
optical activity
[α]19/D +37°, c = 1 in chloroform
Water Solubility 
Insoluble in water.
BRN 
4316842
InChIKey
IBDIOGYTZBKRGI-LLVKDONJSA-N
CAS DataBase Reference
117049-14-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29051990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
429821
Product name
(+)-N-Boc-L-α-phenylglycinol
Purity
99%
Packaging
1g
Price
$27.2
Updated
2025/07/31
TCI Chemical
Product number
B3272
Product name
N-(tert-Butoxycarbonyl)-L-2-phenylglycinol
Purity
>98.0%(GC)
Packaging
1g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
B3272
Product name
N-(tert-Butoxycarbonyl)-L-2-phenylglycinol
Purity
>98.0%(GC)
Packaging
5g
Price
$88
Updated
2025/07/31
TRC
Product number
B942813
Product name
(S)-tert-Butyl(2-Hydroxy-1-phenylethyl)carbamate
Packaging
500mg
Price
$60
Updated
2021/12/16
TRC
Product number
B942813
Product name
(S)-tert-Butyl(2-Hydroxy-1-phenylethyl)carbamate
Packaging
2.5g
Price
$75
Updated
2021/12/16
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BOC-L-Phenylglycinol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

N-Boc-L-alpha-phenylglycinol is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dye fields. Phenylglycinol-derived oxazolopiperidone lactams is used as starting materials for the enantioselective synthesis of piperidine-containing alkaloids.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

56613-80-0

67341-01-9

GENERAL STEPS: Di-tert-butyl dicarbonate (31.82 g, 146.8 mmol) was slowly added to a solution of anhydrous tetrahydrofuran (292 mL) containing (R)-(-)-2-phenylglycinol (20.00 g, 145.8 mmol) and triethylamine (24.4 mL, 175.0 mmol) at 0 °C. The reaction mixture was stirred continuously for 3 hours at 0 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure by rotary evaporator. The concentrated residue was dissolved in dichloromethane (200 mL) and washed with 1N hydrochloric acid (240 mL). The aqueous layer was back-extracted with dichloromethane (2 x 100 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated again by rotary evaporator under reduced pressure to give a white solid product ((R)-tert-butyl 2-hydroxy-1-phenylethyl)carbamate (34.59 g, yield >99%). The product was characterized by 1H NMR (CDCl3): δ 1.43 (s, 9H), 2.29 (br s, 1H), 3.84-3.87 (m, 2H), 4.79 (br s, 1H), 7.29-7.39 (m, 5H).

References

[1] Tetrahedron Asymmetry, 2007, vol. 18, # 23, p. 2758 - 2767
[2] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 28
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[4] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547
[5] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 38 - 42

BOC-L-Phenylglycinol Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-Phenylglycinol Suppliers

Americas 1 Canada 1 China 214 Europe 1 Germany 4 India 12 Japan 4 Switzerland 1 United Kingdom 7 United States 30 Global 275
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
VladaChem GmbH
Tel
+49-7246-3082843
Email
info@vladachem.de
Country
Germany
ProdList
1859
Advantage
58
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from BOC-L-Phenylglycinol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Phg-Ol 117049-14-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-17
Career Henan Chemical Co
Product
BOC-L-Phenylglycinol 117049-14-6
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-16

117049-14-6, BOC-L-PhenylglycinolRelated Search:

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  • Amino Alcohols
  • Amino Acid Derivatives
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Acid Derivatives
  • Amino Acids