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Ethyl methanesulfonate

Product Name
Ethyl methanesulfonate
CAS No.
62-50-0
Chemical Name
Ethyl methanesulfonate
Synonyms
EMS;ETHYL MESYLATE;METHANESULFONIC ACID ETHYL ESTER;CB 1528;Ethyl methansulfonate;ETHYL METHANESULPHONATE;ethylesterofmethylsulfonicacid;ethylesterofmethanesulfonicacid;ethylesterofmethylsulphonicacid;ethylesterofmethanesulphonicacid
CBNumber
CB4292779
Molecular Formula
C3H8O3S
Formula Weight
124.16
MOL File
62-50-0.mol
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Ethyl methanesulfonate Property

Melting point:
<25 °C
Boiling point:
85-86 °C/10 mmHg (lit.)
Density 
1.206 g/mL at 20 °C
vapor pressure 
0.27 hPa (25 °C)
refractive index 
n20/D 1.418(lit.)
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
50-100g/l
form 
liquid
color 
Colourless to Pale Yellow
Water Solubility 
Miscible with water.
Sensitive 
Moisture Sensitive
Merck 
14,3827
BRN 
773969
Stability:
Stable. Combustible. Incompatible with water, alkalies, oxidizing agents.
InChIKey
PLUBXMRUUVWRLT-UHFFFAOYSA-N
CAS DataBase Reference
62-50-0(CAS DataBase Reference)
NIST Chemistry Reference
Methanesulfonic acid, ethyl ester(62-50-0)
IARC
2B (Vol. 7, Sup 7) 1987
EPA Substance Registry System
Ethyl methanesulfonate (62-50-0)
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Safety

Hazard Codes 
T
Risk Statements 
46-22-40-36/37/38-45
Safety Statements 
53-23-36/37/39-45-36/37-37/39-26
RIDADR 
2810
WGK Germany 
3
RTECS 
PB2100000
10-21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29041000
Hazardous Substances Data
62-50-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M0880
Product name
Ethyl methanesulfonate
Purity
liquid
Packaging
1g
Price
$43.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20774
Product name
Ethyl methanesulfonate
Purity
for synthesis
Packaging
5ml
Price
$47
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20774
Product name
Ethyl methanesulfonate
Purity
for synthesis
Packaging
25mL
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
72945
Product name
Ethyl methanesulfonate
Purity
certified reference material, TraceCERT
Packaging
120mg
Price
$131
Updated
2024/03/01
TCI Chemical
Product number
M0607
Product name
Ethyl Methanesulfonate
Purity
>99.0%(GC)
Packaging
25g
Price
$51
Updated
2024/03/01
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Ethyl methanesulfonate Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Chemical Properties

Ethyl methane sulfonate is a clear liquid.

Uses

Ethyl methanesulfonate is used as mutagen for both mammalian and plant cells. It finds application as a model alkylating agent in the study of deoxyribonucleic acid (DNA) repair processes.

Uses

Experimentally as mutagen, teratogen and brain carcinogen.

Definition

ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol.

General Description

Clear colorless liquid. Denser than water.

Air & Water Reactions

Water soluble.

Reactivity Profile

Ethyl methanesulfonate alkylates nucleophiles such as hydroxy, amino and sulfhydryl groups in model and biological materials. Is hydrolyzed by excess aqueous alkali to non-corrosive and non-toxic products. Is hydrolyzed by water to a highly corrosive product .

Fire Hazard

Ethyl methanesulfonate is combustible.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES and ESTERS.

Potential Exposure

Used as a research tool for mutagenesis and carcinogenesis studies. Was considered as a possible human male contraceptive. Also considered as a reversible male hemosterilant for insects and mammalian pests.

Carcinogenicity

Ethyl methanesulfonate is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Contact with moisture may cause hydrolysis or other forms of decomposition

Ethyl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl methanesulfonate Suppliers

Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from Ethyl methanesulfonate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Ethyl methanesulfonate 62-50-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-05-09
Hebei Weibang Biotechnology Co., Ltd
Product
Ethyl methanesulfonate 62-50-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethyl Methanesulfonate 62-50-0
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-08

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