BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
- Product Name
- BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
- CAS No.
- 187039-57-2
- Chemical Name
- BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
- Synonyms
- (2S,3S)-1-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;BOC-TRANS-3-HYDROXY-L-PROLINE;trans-N-Boc-3-hydroxy-L-proline;(2S,3S)-N-Boc-3-hydroxy-L-proline;BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;BOC-(2S,3S)-3-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID;1-(1,1-Dimethylethyl) (2S,3S)-3-hydroxy-1,2-pyrrolidinedicarboxylate;(2S,3S)-3-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;( 2S, 3S)-3-hydroxy-pyrrolidine-1,2-dicarboxylic acid tert butyl ester;(2S,3S)-3-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
- CBNumber
- CB4296151
- Molecular Formula
- C10H17NO5
- Formula Weight
- 231.25
- MOL File
- 187039-57-2.mol
BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Property
- Melting point:
- 157℃
- Boiling point:
- 390.9±42.0 °C(Predicted)
- Density
- 1.312±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- pka
- 3.69±0.40(Predicted)
- Appearance
- White to light brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 292660
- Product name
- (2S,3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
- Packaging
- 1.00g
- Price
- $144
- Updated
- 2026/05/19
- Product number
- 292660
- Product name
- (2S,3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
- Packaging
- 5.00g
- Price
- $566
- Updated
- 2026/05/19
- Product number
- 292660
- Product name
- (2S,3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
- Packaging
- 25.00g
- Price
- $1902
- Updated
- 2026/05/19
- Product number
- C29749
- Product name
- (2S,3S)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $37
- Updated
- 2026/05/06
- Product number
- C29749
- Product name
- (2S,3S)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2026/05/06
BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
184046-78-4
187039-57-2
General procedure for the synthesis of N-Boc-(2S,3S)-(2S,3S)-3-hydroxy-2-carboxypyrrolidine from (2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester: to 1-(tert-butoxycarbonyl)-2-methyl-(2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate (0.30 g, 1.22 mmol) in a tetrahydrofuran (12 mL) solution was added to 0.2N aqueous lithium hydroxide (6.12 mL, 1.22 mmol). The reaction mixture was stirred at room temperature for 3 hours. After the reaction was completed, the reaction mixture was diluted with ether (30 mL) and extracted with 0.2N aqueous lithium hydroxide solution (3 x 5 mL). The aqueous layers were combined and acidified with 5% aqueous hydrochloric acid to pH=2. The acidic aqueous layer was extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford N-Boc-(2S,3S)-3-hydroxy-2-carboxypyrrolidine as a gel (0.25 g, 88% yield), which was used directly in the next reaction. Mass spectrum (ES+) m/z 230.3 (M+1).
References
[1] Patent: WO2016/7534, 2016, A1. Location in patent: Page/Page column 171; 172
BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID manufacturers
- Product
- (2S,3S)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 187039-57-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26