2-Chloro-5-aminophenol
- Product Name
- 2-Chloro-5-aminophenol
- CAS No.
- 6358-06-1
- Chemical Name
- 2-Chloro-5-aminophenol
- Synonyms
- 2-Chloro-5-Aminopheno;5-AMINO-2-CHLOROPHENOL;2-CHLORO-5-AMINOPHENOL;5-amino-2-chloro-pheno;3-amino-6-chlorophenol;2-ch1oro-5-aminophenol;5-azanyl-2-chloro-phenol;4-Chloro-3-hydroxyaniline;Phenol, 5-amino-2-chloro-;5-Amino-2-chlorophenol >
- CBNumber
- CB4296636
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 6358-06-1.mol
2-Chloro-5-aminophenol Property
- Melting point:
- 160 °C
- Boiling point:
- 185.5°C (rough estimate)
- Density
- 1.2028 (rough estimate)
- refractive index
- 1.5618 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO, Methanol
- form
- Powder
- pka
- 8.55±0.10(Predicted)
- color
- Gray
- Sensitive
- Light Sensitive
- InChIKey
- JSCNCRWPXOTDDZ-UHFFFAOYSA-N
- CAS DataBase Reference
- 6358-06-1(CAS DataBase Reference)
- EPA Substance Registry System
- Phenol, 5-amino-2-chloro- (6358-06-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A1976
- Product name
- 5-Amino-2-chlorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- A1976
- Product name
- 5-Amino-2-chlorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- A603890
- Product name
- 5-Amino-2-chlorophenol
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4656-5-Z1
- Product name
- 5-Amino-2-chlorophenol
- Packaging
- 25g
- Price
- $108
- Updated
- 2021/12/16
- Product number
- FC38394
- Product name
- 2-Chloro-5-aminophenol
- Packaging
- 10g
- Price
- $110
- Updated
- 2021/12/16
2-Chloro-5-aminophenol Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
5-Amino-2-chlorophenol is used in the synthesis of antimalarial quinolones. Also used in the synthesis of potent anti-HIV agents based upon pyrimidinylphenylamine 1.
Synthesis
619-10-3
6358-06-1
Step 1: 2-Chloro-5-nitrophenol (20.0 g, 115.2 mmol) was dissolved in a solvent mixture of ethanol (150 mL) and water (150 mL). To this solution, iron powder (32.2 g, 576.2 mmol) and ammonium chloride (32.1 g, 599.3 mmol) were added sequentially. The reaction mixture was heated to reflux and kept for 2 hours. After completion of the reaction, it was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated to dryness under reduced pressure. The residue was purified by fast column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford 5-amino-2-chlorophenol (15.85 g, 96% yield) as a white solid.
References
[1] Patent: US2003/100580, 2003, A1
[2] Patent: US2010/160388, 2010, A1. Location in patent: Page/Page column 58
[3] Patent: US2010/160389, 2010, A1. Location in patent: Page/Page column 49
[4] Patent: US2011/28502, 2011, A1. Location in patent: Page/Page column 44-45
[5] Patent: US2011/71143, 2011, A1. Location in patent: Page/Page column 36
2-Chloro-5-aminophenol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-aminophenol Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from 2-Chloro-5-aminophenol manufacturers
- Product
- 2-chloro-5-Aminophenol 6358-06-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07
- Product
- 2-Chloro-5-aminophenol 6358-06-1
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21
- Product
- 2-Chloro-5-aminophenol 6358-06-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0% min
- Supply Ability
- 10tons/month
- Release date
- 2023-06-13