6-FLUORO-1H-INDAZOL-3-YLAMINE
- Product Name
- 6-FLUORO-1H-INDAZOL-3-YLAMINE
- CAS No.
- 404827-75-4
- Chemical Name
- 6-FLUORO-1H-INDAZOL-3-YLAMINE
- Synonyms
- 6-Fluoro-2h-indazol-3-amine;6-fluoro-1H-indazol-3-aMine;6-Fluoro-1H-indazol-4-ylamine;6-FLUORO-1H-INDAZOL-3-YLAMINE;1H-Indazol-3-amine, 6-fluoro-;1H-Indazol-3-amine,6-fluoro-(9CI)
- CBNumber
- CB4296742
- Molecular Formula
- C7H6FN3
- Formula Weight
- 151.14
- MOL File
- 404827-75-4.mol
6-FLUORO-1H-INDAZOL-3-YLAMINE Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F595163
- Product name
- 6-Fluoro-1h-indazol-3-ylamine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- F595163
- Product name
- 6-Fluoro-1h-indazol-3-ylamine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC908712
- Product name
- 6-Fluoro-1H-indazol-3-amine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 3H30-3-69
- Product name
- 6-Fluoro-1H-indazol-3-amine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- PC908712
- Product name
- 6-Fluoro-1H-indazol-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
6-FLUORO-1H-INDAZOL-3-YLAMINE Chemical Properties,Usage,Production
Synthesis
3939-09-1
404827-75-4
General procedure for the synthesis of 3-amino-6-fluoro-1H-indazole from 2,4-difluorobenzonitrile: 2,4-difluorobenzonitrile (10.00 g, 71.89 mmol) was placed in a 500 mL two-necked round-bottomed flask and n-butanol (200 mL) was added as a solvent. Hydrazine hydrate (70.0 mL, 1443 mmol) was slowly added to the reaction system under nitrogen protection. After addition, the reaction mixture was heated to 150 °C and stirred continuously for 17 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (200 mL x 3). The organic phases were combined, washed sequentially with water (200 mL x 2) and saturated saline (200 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (v/v=1/2) to afford 3-amino-6-fluoro-1H-indazole as a yellow liquid (4.85 g, 44.7% yield). Mass spectrum (ESI, positive ion mode) m/z: 152.2 ([M+H]+).
References
[1] Patent: WO2018/188590, 2018, A1. Location in patent: Paragraph 00316
[2] Patent: US2009/270405, 2009, A1. Location in patent: Page/Page column 82-83
[3] Patent: WO2011/53292, 2011, A1. Location in patent: Page/Page column 133
[4] Patent: JP5714745, 2015, B2. Location in patent: Paragraph 0264; 0265
6-FLUORO-1H-INDAZOL-3-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-FLUORO-1H-INDAZOL-3-YLAMINE manufacturers
- Product
- 6-FLUORO-1H-INDAZOL-3-YLAMINE 404827-75-4
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09