MIDODRINE

Product Name: MIDODRINE
CAS No.: 42794-76-3
Chemical Name: MIDODRINE
Synonyms: MIDODRINE;MIDODRINE USP/EP/BP;Midodrine (metoclopramide);2-Amino-N-(2,5-dimethoxy-β-hydroxyphenethyl)acetamide;Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-;Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]- (9CI)
CBNumber: CB4297224
Molecular Formula: C12H18N2O4
Formula Weight: 254.28
MOL File: 42794-76-3.mol

More

Less

MIDODRINE Property

Boiling point:: 529.9±50.0 °C(Predicted)
Density: 1.204±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 13.47±0.20(Predicted)

More

Less

Safety

Hazardous Substances Data: 42794-76-3(Hazardous Substances Data)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Crysdot

Product number: CD31001926
Product name: Midodrine
Purity: 98+%
Packaging: 5mg
Price: $56
Updated: 2021/12/16

Crysdot

Product number: CD31001926
Product name: Midodrine
Purity: 98+%
Packaging: 10mg
Price: $77
Updated: 2021/12/16

Crysdot

Product number: CD31001926
Product name: Midodrine
Purity: 98+%
Packaging: 50mg
Price: $315
Updated: 2021/12/16

DC Chemicals

Product number: DC24075
Product name: Midodrine
Purity: >98%
Packaging: 50mg
Price: $318
Updated: 2021/12/16

DC Chemicals

Product number: DC24075
Product name: Midodrine
Purity: >98%
Packaging: 100mg
Price: $528
Updated: 2021/12/16

More

Less

MIDODRINE Chemical Properties,Usage,Production

Originator

Gutron,Hormonchemie,W. Germany,1977

Uses

Antihypotensive.

Definition

ChEBI: An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydro hloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Manufacturing Process

19.5 parts of carbobenzoxyglycine, 7.1 parts of triethylamine and 162 parts ofdry toluene are mixed with 11.2 parts of isovaleric acid chloride at 0°C toform the mixed anhydride and the mixture is agitated for two hours at 0°C.32.4 parts of 1-(2',5'-dimethoxyphenyl)-2-aminoethanol-(1) are then added,the mixture is agitated for four hours at a temperature between 0°C and+10°C and then left to stand overnight at that temperature. A thick crystalpaste forms. The reaction product is dissolved in 450 parts of ethyl acetateand 200 parts of water. The ethyl acetate solution is separated, washed withhydrochloric acid, sodium bicarbonate solution and water, dried over sodiumsulfate and inspissated. The inspissation residue is digested with 342 parts ofxylene, the required product crystallizing out. 34.9 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are obtained.66.2 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are hydrogenated in the presence of 6.6 parts of palladium carbon(10%) in 2,000 parts of glacial acetic acid. When no more hydrogen isabsorbed (3 mols of hydrogen are used), hydrogenation stops. The catalyst isremoved by suction and the equivalent quantity of hydrochloric acid in ethanolis added to the filtrate with agitation. During further agitation at roomtemperature 28.6 parts of crude 1-(2',5'-dimethoxyphenyl)-2-glycineamidoethanol-(1)hydrochloride crystallize, and are isolated andrecrystallized from water-methanol for purification. 22.1 parts of pure productare obtained with a melting point of 192°C to 193°C.
An alternative synthesis route is described by Kleeman and Engel.

brand name

Orvaten (UpsherSmith); Proamatine (Shire).

Therapeutic Function

Peripheral vasotonic, Antihypotensive

MIDODRINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MIDODRINE Suppliers

China 28 Germany 2 India 1 United Kingdom 2 United States 12 Global 45

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9293
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4392
Advantage: 58

Hebei Mojin Biotechnology Co., Ltd

Tel: +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12467
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28812
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9177
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569265 +86-18612256290
Fax: 029-88380327
Email: 1056@dideu.com
Country: China
ProdList: 3430
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856359 18690052321
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4576
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Hebei ruqi technology co., ltd

Tel: 176-03256889 17603256889
Email: 1123722730@qq.com
Country: China
ProdList: 3390
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2999
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb5@aikonchem.com
Country: China
ProdList: 10529
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48518
Advantage: 58

Chengdu Aupone Pharmaceutical Co.Ltd.

Tel: +86-28-+86-28-87843998-6060-6060 +8618631098571
Fax: +86-28-87843335
Email: lijiaqi@aupone.com
Country: China
ProdList: 43
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 50000
Advantage: 58

Lihe Pharm Technology（Wuhan）Co.,Ltd

Tel: +8618071517867
Email: info@lihepharma.com
Country: China
ProdList: 194
Advantage: 58

Hebei Duling International Trade Co. LTD

Tel: +8618032673083
Fax: 0311-87836622
Email: sales05@hbduling.cn
Country: China
ProdList: 15743
Advantage: 58

More

Less

View Lastest Price from MIDODRINE manufacturers

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: Midodrine 42794-76-3
Price: US $0.00/gram
Min. Order: 10gram
Purity: 99.99
Supply Ability: 10Tons
Release date: 2024-03-18

Shaanxi Dideu Medichem Co. Ltd

Product: Midodrine 42794-76-3
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Hebei Mojin Biotechnology Co., Ltd

Product: MIDODRINE 42794-76-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-06-02

42794-76-3, MIDODRINERelated Search:

Imipramine hydrochloride Oxybutynin Torasemide Donepezil Tamsulosin MIDODRINE,MIDODRINE HCL,MIDODRINE HYDROCHLORIDE MIDODRINE-D6 HCL

MIDODRINE

Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]- (9CI)

2-Amino-N-(2,5-dimethoxy-β-hydroxyphenethyl)acetamide

Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-

MIDODRINE USP/EP/BP

Midodrine (metoclopramide)

42794-76-3