Lafutidine

ChemicalBook > CAS DataBase List > Lafutidine

Description References

Product Name: Lafutidine
CAS No.: 118288-08-7
Chemical Name: Lafutidine
Synonyms: Stogar;LACTITOL;frg-8813;Protecadin;LAFUTIDINE;Laflutidine;118288-08-07;enyl)acetamide;Lafutidine API;Lafutidine Tablets
CBNumber: CB4297653
Molecular Formula: C22H29N3O4S
Formula Weight: 431.55
MOL File: 118288-08-7.mol

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Lafutidine Property

Melting point:: 92.7-94.9°
Boiling point:: 704.2±60.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
Water Solubility: Insoluble in water
solubility: DMF:5.0(Max Conc. mg/mL);11.59(Max Conc. mM)
DMSO:48.67(Max Conc. mg/mL);112.77(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:10):0.09(Max Conc. mg/mL);0.21(Max Conc. mM)
Ethanol:9.0(Max Conc. mg/mL);20.86(Max Conc. mM)
form: powder to crystal
pka: 13.13±0.46(Predicted)
color: White to Orange to Green
CAS DataBase Reference: 118288-08-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: L0341
Product name: Lafutidine
Packaging: 25MG
Price: $17
Updated: 2024/03/01

TCI Chemical

Product number: L0341
Product name: Lafutidine
Packaging: 1G
Price: $273
Updated: 2024/03/01

Cayman Chemical

Product number: 30275
Product name: Lafutidine
Packaging: 25mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 30275
Product name: Lafutidine
Packaging: 50mg
Price: $84
Updated: 2024/03/01

TCI Chemical

Product number: L0341
Product name: Lafutidine
Packaging: 250MG
Price: $100
Updated: 2024/03/01

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Lafutidine Chemical Properties,Usage,Production

Description

Lafutidine is a second generation of H2-receptor antagonist. H2-receptor antagonist can strongly inhibit gastric acid secretion compared with conventional drugs such as antacids. Unlike conventional H2-receptor antagonist, lafutidine inhibits gastric acid secretion during daytime as well as nighttime in clinical studies in humans. Lafutidine also has gastroprotective activity independent of its acid antisecretory efficacy, preventing noxious agent-induced gastric mucosal injury and accelerating the repair process following gastric mucosal damage. It also protects experimentally induced reflux esophagitis, indomethacin-induced intestinal, and dextran sulfate sodium-induced colonic inflammation.
Lafutidine is used for gastric and duodenal ulcers. It is also confirmed that lafutidine can be used as an empiric treatment and superior efficacy for primary care practice patients with dyspepsia.

References

[1] Tomohiko Shimatani, Masaki Inoue, Tomoko Kuroiwa, Jing Xu, Masuo Nakamura, Susumu Tazuma, Kazuro Ikawa, Norifumi Morikawa (2006) Lafutidine, a Newly Developed Antiulcer Drug, Elevates Postprandial Intragastric pH and Increases Plasma Calcitonin Gene-Related Peptide and Somatostatin Concentrations in Humans: Comparisons with Famotidine, Digestive Diseases and Sciences, 51, 114-120
[2] Bhupesh Dewan, Nisha Philipose (2011) Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial, Gastroenterology Research and Practice, 2011, Article ID 640685
[3] https://www.drugs.com

Description

Lafutidine was launched in Japan for the treatment of gastritis, reflux oesophagitis and peptic ulcers. It can be prepared in eight steps from 4-(2-tetrahydropyranyloxy)-2(Z)-butenl- ol. Lafutidine is a potent and longer-acting H₂ antagonist compared to other marketed compounds of its class such as cimetidine and famotidine. In contrast to other commercially available H₂ antagonists, lafutidine also exerts a gastroprotective action probably via capsaicin-sensitive afferent nerves. It was clinically effective in the treatment of nonsteroidal antiinflammatory drug-induced ulcer in patients refractory to existing antiulcer agents.

Description

Lafutidine is a histamine H₂ receptor antagonist with gastroprotective activity. It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H₂ receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis. It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1^-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg. Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.

Originator

Fujirebio (Japan)

Uses

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide is a Histaminic H2 receptor antagonists in ulcer disease. Also, it is a model compound used to investigate the binding mechanism between antiulcer drugs and human serum albumin (HSA).

Uses

Second generation histamine H2-receptor antagonist. Antiulcerative

Uses

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion

Definition

ChEBI: Lafutidine is an organic molecular entity.

brand name

Stogar, Protecadin

Lafutidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lafutidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lafutidine 118288-08-7
Price: US $0.00/Kg/Bag
Min. Order: 10g
Purity: 98.5%min
Supply Ability: 10kg
Release date: 2021-11-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: Lafutidine 118288-08-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Lafutidine 118288-08-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

118288-08-7, LafutidineRelated Search:

Omeprazole Famotidine Ranitidine Lafutidine N-{4-[4-(PIPERIDINOMETHYL)PYRIDYL-2-OXY]-CIS-2-BUTENE}PHTHALIMIDE MALEIC ACID(INTERMEDIATE FOR LAFUTIDINE) LACTITOL MONOHYDRATE,LACTITOL H2O,D-LACTITOL MONOHYDRATE,LACTITOL MONOHYDRATE 99% p-Nitrophenyl 2-(Furfurylsulfinyl)acetate 4-[4-(Piperidinomethyl)pyridyl-2-oxy]-cis-2-butenamine 2-ALLYLOXYPYRIDINE LACTITOL (Z)-4-[(TETRAHYDRO-2H-PYRAN-2-YL)OXY]-2-BUTEN-1-OL (PREPARATION FOR LAFUTIDINE) Lomerizine Furan Acetamide 2-Butene 2(1H)-Pyridinone,4-(aminomethyl)-(9CI) 2-((FURAN-2-YL)METHYLSULFINYL)-N-((Z)-4-HYDROXYBUT-2-ENYL)ACETAMIDE N-(PYRIDIN-4-YLMETHYL)BUTAN-1-AMINE

n-(4-(4-piperidinylmethyl)pyridyl-2-oxy)butenyl-2-(furfurylsulfinyl)acetamide

2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide

(Z)-2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide

Adefovir Dipivioxil

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-

LAFUTIDINE(SUBJECTTOPATENTFREE)

118288-08-07

LACTITOL

2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide

Laflutidine

Protecadin

Stogar

2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)4-[[4-(1-piperidinylmethyl)-2-pyridinyl] oxy]-2-butenyl]-acetamide

LAFUTIDINE

(+-)-2-(furfurylsulfinyl)-n-(4-(4-(piperidinomethyl)-2-pyridyl)oxy-(z)-2-but

(z)-inyl)oxy)-2-butenyl)

acetamide,2-((2-furanylmethyl)sulfinyl)-n-(4-((4-(1-piperidinylmethyl)-2-pyrid

enyl)acetamide

frg-8813

2-(2-furanylmethylsulfinyl)-N-[2-hydroxy-4-[4-(4-piperidinylmethyl)-2-pyridinyl]but-1-enyl]acetamide

Lafutidine Lafutidine

(Z)-2-[(Furan-2-ylmethyl)sulfinyl]-N-[4-[[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy]but-2-en-1-yl]acetamide

Lafutidine USP/EP/BP

2-(furan-2-ylmethylsulfinyl)-N-[(Z)-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide

(+)-(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide

Lafutidine (FRG-8813)

LafutidineQ: What is Lafutidine Q: What is the CAS Number of Lafutidine Q: What is the storage condition of Lafutidine Q: What are the applications of Lafutidine

Lafutidine API

R)-Palonosetron Hydrochloride

Lafutidine Tablets

118288-08-7

118288-89-7

118288-08-07

118288-08-1

18288-08-7

C22H29N3O4S

Other APIs

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Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds