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LACTITOL

Product Name
LACTITOL
CAS No.
585-86-4
Chemical Name
LACTITOL
Synonyms
Lactit;Lactnol;Lactite;LACTITOL;Importal;Lactit M;Lactosit;Finlac DC;D-Lactitol;Lactiobiosit
CBNumber
CB5363096
Molecular Formula
C12H24O11
Formula Weight
344.31
MOL File
585-86-4.mol
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LACTITOL Property

Melting point:
146°
alpha 
D23 +14° (c = 4 in water)
Boiling point:
788.5±60.0 °C(Predicted)
Density 
1.69±0.1 g/cm3(Predicted)
solubility 
Slightly soluble in ethanol (95%) and ether. Soluble 1 in 1.75 of water at 20°C; 1 in 1.61 at 30°C; 1 in 1.49 at 40°C; 1 in 1.39 at 50°C.
pka
12.84±0.70(Predicted)
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Safety

Hazardous Substances Data
585-86-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1356687
Product name
Lactitol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500 mg
Price
$414
Updated
2021/03/22
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LACTITOL Chemical Properties,Usage,Production

Description

Lactitol (4-o-(|3-D-Galactopyranosyl)-D-glucitol) is a disaccharide sugar alcohol derived from lactose by reduction of its glucose moiety. Lactitol has not been found in nature. It is about 0.4 times as sweet as sucrose.
In vitro studies with galactosidase-containing enzyme preparations have demonstrated that lactitol is hydrolyzed only very slowly. In incubations with human intestinal biopsies, it has been shown that the human intestinal mucosa does not exhibit any significant dis accharidase activity with lactitol as a substrate. The hydrolytic activities towards lactitol and isomalt were only 1.3% of those towards lactose and isomaltulose, respectively. Corresponding exper iments with intestinal preparations of germ-free pigs and convention ally kept minipigs gave similar results. These observations indicate that lactitol is the most slowly digested disaccharide sugar alcohol. However, in vitro investigations with intestinal enzyme prepara tions provide only relative figures on hydrolysis rates. Experiments with humans and 14C-labeled lactitol during jejunal perfusion indi cate that lactitol is virtually not assimilated by the human small intestine. After passage through the small intestine, ingested lac titol reaches the bacterially colonized segments of the gut where intensive fermentation takes place. Short-chain fatty acids (acetate, propionate, butyrate) are the major fermentation end products which are subsequently further metabolized by the host.
Lactitol is slowly fermented in growing cultures by some strepto cocci, actinomyces and lactobacilli. When fed at 25% of the diet to rats that had been inoculated with Streptococcus mutans, lactitol was about equally as cariogenic as sorbitol and significantly less cariogenic than sucrose. Test candies and chocolates sweetened by lactitol are hypoacidogenic in humans tested by plaque pH telemetry. Boiled sweets made with 100% lactitol are rough in texture owing to crystallization, and caused some gastrointestinal upsets in human volunteers. Since lactitol has only one-third the sweetness of sucrose, sweets need an additional sweetening agent for palatability.

Chemical Properties

Lactitol occurs as white orthorhombic crystals. It is odorless with a sweet taste that imparts a cooling sensation. It is available in powdered form and in a range of crystal sizes. The directly compressible form is a water-granulated product of microcrystalline aggregates.

Production Methods

Lactitol is produced by the catalytic hydrogenation of lactose.

Pharmaceutical Applications

Lactitol is used as a noncariogenic replacement for sucrose. It is also used as a diluent in solid dosage forms.(1) A direct-compression form is available,(2,3) as is a direct-compression blend of lactose and lactitol. Lactitol is also used therapeutically in the treatment of hepatic encephalopathy and as a laxative.

Safety

Lactitol is regarded as a nontoxic and nonirritant substance. It is not fermented significantly in the mouth, and is not cariogenic.It is not absorbed in the small intestine, but is broken down by microflora in the large intestine, and is metabolized independently of insulin. In large doses it has a laxative effect; therapeutically, 10–20 g daily in a single oral dose is administered for this purpose.
LD50 (mouse, oral): >23 g/kg
LD50 (rat, oral): 30 g/kg

storage

Lactitol as the monohydrate is nonhygroscopic and is stable under humid conditions. It is stable to heat and does not take part in the Maillard reaction. In acidic solution, lactitol slowly hydrolyzes to sorbitol and galactose. Lactitol is very resistant to microbiological breakdown and fermentation. Store in a well-closed container. When the compound is stored in an unopened container at 25°C and 60% relative humidity, a shelf-life in excess of 3 years is appropriate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

LACTITOL Preparation Products And Raw materials

Raw materials

Preparation Products

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LACTITOL Suppliers

Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241- ;027-59599240-
Fax
027-59599241
Email
1400878000@qq.com;1400868000@qq.com
Country
China
ProdList
9841
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8933
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736-
Email
sales@isomersyn.com
Country
China
ProdList
3300
Advantage
57
BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2950
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847-
Fax
021-55068248
Email
3008007399@qq.com
Country
China
ProdList
4995
Advantage
60
XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.
Tel
86-029-85456576
Fax
86-029-85456576-808
Email
daisy_wang@vip.163.com
Country
China
ProdList
293
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3756
Advantage
55
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
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View Lastest Price from LACTITOL manufacturers

Hebei Yirun Sega Biological Technology Co. Ltd
Product
Lactitol 585-86-4
Price
US $2.00/KG
Min. Order
1000KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-11-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lactitol 585-86-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10tons/month
Release date
2021-07-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
LACTITOL 585-86-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

585-86-4, LACTITOLRelated Search:


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