N,N'-Diisopropylcarbodiimide

Product Name: N,N'-Diisopropylcarbodiimide
CAS No.: 693-13-0
Chemical Name: N,N'-Diisopropylcarbodiimide
Synonyms: DIC;Diisopropylcarbodiimide;DIPC;DIPCI;DIPCDI;N,N-DIISOPROPYLCARBODIIMIDE;PCI;DICI;1,3-DIISOPROPYLCARBODIIMIDE;Diisopropylcarbodiimide solution
CBNumber: CB4301572
Molecular Formula: C7H14N2
Formula Weight: 126.2
MOL File: 693-13-0.mol

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N,N'-Diisopropylcarbodiimide Property

Melting point:: 210-2120C (dec)
Boiling point:: 145-148 °C(lit.)
Density: 0.815 g/mL at 20 °C(lit.)
vapor pressure: 34.9hPa at 55.46℃
refractive index: n20/D 1.433(lit.)
Flash point:: 93 °F
storage temp.: Store below +30°C.
solubility: Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form: Liquid
color: Clear colorless to yellow
Sensitive: Moisture Sensitive
BRN: 878281
Stability:: Volatile
InChIKey: BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP: 4.11 at 20℃
CAS DataBase Reference: 693-13-0(CAS DataBase Reference)
NIST Chemistry Reference: 2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System: 2-Propanamine, N,N'-methanetetraylbis- (693-13-0)

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Safety

Hazard Codes: T+,T,F,Xn
Risk Statements: 10-26-36/37/38-41-42/43-37/38
Safety Statements: 26-36/37/39-45-38-28A-16-22
RIDADR: UN 2929 6.1/PG 1
WGK Germany: 3
RTECS: FF2175000
F: 10-21
Hazard Note: Flammable/Highly Toxic/
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29252000
Hazardous Substances Data: 693-13-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H317May cause an allergic skin reaction

H318Causes serious eye damage

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.03649
Product name: N,N′-Diisopropylcarbodiimide
Purity: for synthesis
Packaging: 10ml
Price: $51.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.03649
Product name: N,N′-Diisopropylcarbodiimide
Purity: for synthesis
Packaging: 25mL
Price: $99.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.03649
Product name: N,N′-Diisopropylcarbodiimide
Purity: for synthesis
Packaging: 100mL
Price: $261
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.03649
Product name: N,N′-Diisopropylcarbodiimide
Purity: for synthesis
Packaging: 1L
Price: $1170
Updated: 2024/03/01

Sigma-Aldrich

Product number: 38370
Product name: DIC
Purity: purum, ≥98.0% (GC)
Packaging: 25ml
Price: $89.6
Updated: 2024/03/01

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N,N'-Diisopropylcarbodiimide Chemical Properties,Usage,Production

Description

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Chemical Properties

N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.

Uses

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. It is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.

Definition

ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.

General Description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Contact allergens

It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.

Synthesis

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.

N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials

Raw materials

MOLECULAR SIEVES PACK 4A 1,2-DIETHOXYDISULFANE LEAD CARBONATE Benzene Dichloromethane N,N'-DIISOPROPYLTHIOUREA

Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE

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N,N'-Diisopropylcarbodiimide Suppliers

Americas 1 Australia 1 Belgium 3 Canada 5 China 446 Europe 5 France 3 Germany 11 Hungary 1 India 26 Israel 1 Japan 12 Slovakia 1 South Korea 1 Switzerland 4 The Netherlands 1 United Kingdom 26 United States 75 Global 623

Alkemi BVBA

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Acros Organics

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View Lastest Price from N,N'-Diisopropylcarbodiimide manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: N,N'-Diisopropylcarbodiimide 693-13-0
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-26

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: N,N'-Diisopropylcarbodiimide 693-13-0
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000Ton
Release date: 2024-08-09

Hebei Zhuanglai Chemical Trading Co Ltd

Product: N,N'-Diisopropylcarbodiimide 693-13-0
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-22

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