DIHYDROLIPOIC ACID

Product Name: DIHYDROLIPOIC ACID
CAS No.: 462-20-4
Chemical Name: DIHYDROLIPOIC ACID
Synonyms: dihydrolipoate;LIPOIC ACID, REDUCED;6,8-DIMERCAPTO-OCTANOIC ACID;DHLA;usafxr-12;USAF XR-12;Dihydroliponsure;reducedlipoicacid;dihydro-lipoicaci;DIHYDROLIPOIC ACID
CBNumber: CB4302519
Molecular Formula: C8H16O2S2
Formula Weight: 208.34
MOL File: 462-20-4.mol

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DIHYDROLIPOIC ACID Property

Melting point:: 62 °C
Boiling point:: 161.5 °C(Press: 0.7 Torr)
Density: 1.132 g/cm3
vapor pressure: 0Pa at 25℃
refractive index: 1.5220-1.5260
storage temp.: +2C to +8C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid
pka: 4.74±0.10(Predicted)
color: light yellow
InChI: InChI=1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)
InChIKey: IZFHEQBZOYJLPK-UHFFFAOYSA-N
SMILES: C(O)(=O)CCCCC(S)CCS
LogP: 1.9 at 20℃
Surface tension: 53.6mN/m at 1.02g/L and 21℃

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: RH0525000
HS Code: 2930.90.4950

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 437694
Product name: DL-α-Lipoic Acid, Dihydro-
Purity: An effective antioxidant.
Packaging: 50mg
Price: $99.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: T8260
Product name: Lipoic acid, reduced
Purity: analytical standard
Packaging: 1g
Price: $584
Updated: 2022/05/15

TCI Chemical

Product number: D4586
Product name: Dihydrolipoic Acid
Packaging: 200MG
Price: $141
Updated: 2025/07/31

TCI Chemical

Product number: D4586
Product name: Dihydrolipoic Acid
Packaging: 1G
Price: $482
Updated: 2025/07/31

Cayman Chemical

Product number: 16372
Product name: Dihydrolipoic Acid
Purity: ≥95%
Packaging: 25mg
Price: $32
Updated: 2024/03/01

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DIHYDROLIPOIC ACID Chemical Properties,Usage,Production

Uses

γ-Lipoic Acid, is a metabolite of α-Lipoic Acid (L468730), which is a over-the-counter nutritional supplements, that has been used as antioxidant. It is also fat-metabolism stimulator, and thus used a "weight loss" and "energy" supplement.

Definition

ChEBI: A thio-fatty acid that is reduced form of lipoic acid. A potent antioxidant shown to directly destroy superoxide, hydroperoxy and hydroxyl radicals; also has neuroprotective and anti-tumour effects.

Biological Activity

Cell permeable: no', 'Primary Target
Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals', 'Product does not compete with ATP.', 'Reversible: no

in vivo

Dihydrolipoic Acid (DHLA) treatment exerts preventive effects in LPS-induced sickness behavior rats. Dihydrolipoic Acid increases the expression of ERK, Nrf2, and HO-1 but decreases the ROS generation levels and reduces the expression of NLRP3, caspase-1, and IL-1β in LPS-induced sickness behavior rats. Dihydrolipoic Acid is a reduced form of α-lipoic acid (LA) that can decrease oxidative stress and act as a strong antioxidant^[2]. Dihydrolipoic Acid treatment reverses the LPS-induced sickness behavior^[2].

Animal Model:	Adult male Sprague-Dawley (SD) rats (weight, 200-220?g)^[2]
Dosage:	15?mg/kg, 30?mg/kg, 60?mg/kg
Administration:	Injected intraperitoneally daily
Result:	Treatment with 30?mg/kg and 60?mg/kg improved the body weight gain as compared to the LPS group.

DIHYDROLIPOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDROLIPOIC ACID Suppliers

Americas 1 Belgium 1 Canada 3 CHINA 111 Europe 1 France 1 Germany 5 India 8 Japan 2 Spain 1 Switzerland 1 United Kingdom 4 United States 25 Global 164

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462-20-4, DIHYDROLIPOIC ACIDRelated Search:

1,2-Dithiolane-3-pentanoic acid 1-oxide rac α-Lipoic Acid-d5 Sodium (R)-alpha-lipoate α-Lipoic Acid Lipoic acid tromethamine salt (+/-)-Dihydrolipoic acid,(+/-)-Dihydrolipoic acid Octanoic acid Lipoic acid R-(+)-Dihydrolipoic acid,R-(+)-Dihydrolipoic acid DIHYDROLIPOIC ACID OCTOTIAMINE 5-[(3S)-Dithiolan-3-yl]pentanoic acid Sodium thioctate D,L-ALPHA-LIPOIC ACID-NHS S-(-)-Dihydrolipoic Acid,S-(-)-Dihydrolipoic Acid 1,2-DITHIOLANE-3-PENTANOIC ACID, [2-3H] R-DHLA(R-DIHYDROLIPOIC ACID ),R-DHLA(R-DIHYDROLIPOIC ACID ) dihydrolipoic acid methyl ester,dihydrolipoic acid methyl ester

DHLA

(+/-)-DIHYDROLIPOIC ACID

DIHYDROLIPOIC ACID

DL-ALPHA-LIPOIC ACID REDUCED FORM

DL-ALPHA-LIPOIC ACID, DIHYDRO-

DL-6,8-THIOCTIC ACID, REDUCED

DL-6,8-THIOCTIC ACID REDUCED FORM

DL-1,2-DITHIOLANE-3-PENTANOIC ACID REDUCED FORM

LIPOIC ACID, REDUCED

THIOCYTIC ACID, DIHYDRO

6,8-Dihydrothioctic acid

6,8-dihydrothiocticacid

dl-dihydro-alpha-6-thiocticacid

Lipoic acid, dihydro-

Reduced lipoic acid

Reduced thioctic acid

reducedlipoicacid

reducedthiocticacid

Thioctic acid, dihydro-

USAF XR-12

usafxr-12

DL-a-Lipoic Acid, Dihydro-

Dihydroliponsure

(±)-6,8-Dimercaptooctanoic acid, (±)-Dihydrolipoic acid, DL-6,8-Thioctic acid, reduced

6,8-Bis(mercapto)octanoic acid

6,8-bis(sulfanyl)octanoic acid

6,8-dimercaptocaprylic acid

DL-α-Lipoic Acid, Dihydro-

Thioctic acid Impurity 1

(+/-)-6,8-DIMERCAPTOOCTANOIC ACID

6,8-DIMERCAPTO-OCTANOIC ACID

6,8-dimercapto-octanoicaci

alpha-Lipoic acid, dihydro-

dihydro-alpha-lipoicaci

dihydrolipoate

dihydro-lipoicaci

Dihydrothioctic acid

dihydro-thiocticaci

dihydrothiocticacid

dl-Dihydro-alpha-6-thioctic acid

DL-α-Lipoic Acid, Dihydro- - CAS 462-20-4 - Calbiochem

Lipoic Acid Impuirty 2

(6R)-6,8-dimercaptooctanoate

6,8-Dimercapto-n-octanoic Acid

8-Dihydrothioctic acid

Lipopolysaccharide,Dihydrolipoic acid,Antioxidant,radical,Reactive Oxygen Species,centered,anti-inflammatory,oxygen,Inhibitor,inhibit,Nrf2,ROS,HO-1,ERK,NLRP3,Depression,Neuroinflammation

6,8-Dimercaptooctanoic acid (Thioctic Acid Impurity)

DL-α-Lipoic Acid, Dihydro-

462-20-4

C8H16O2S2000101g1790

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