Sodium thioctate
- Product Name
- Sodium thioctate
- CAS No.
- 2319-84-8
- Chemical Name
- Sodium thioctate
- Synonyms
- SODIUM LIPOATE;sodium thioctate;α-Lipoic Acid (sodium);alpha-Lipoic Acid Sodium;Thioctic acid sodium salt;ALPHALIPOICACIDSODIUMSALT;Sodium thioctate SODIUM LIPOATE;Sodium 5-(dithiolan-3-yl)pentanoate;sodium 5-(1,2-dithiolan-3-yl)pentanoate;DL-α-Lipoic acid sodium|||(±)-α-Lipoic acid sodium
- CBNumber
- CB4512242
- Molecular Formula
- C8H13NaO2S2
- Formula Weight
- 228.31
- MOL File
- 2319-84-8.mol
Sodium thioctate Property
- form
- solid
- color
- Beige
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- S655028
- Product name
- SodiumThioctate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- V0940
- Product name
- Sodiumthioctate
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- V0940
- Product name
- Sodiumthioctate
- Packaging
- 5g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- ING0002195
- Product name
- SODIUM THIOCTATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $135.45
- Updated
- 2021/12/16
- Product number
- V0940
- Product name
- Sodiumthioctate
- Packaging
- 100g
- Price
- $601
- Updated
- 2021/12/16
Sodium thioctate Chemical Properties,Usage,Production
Uses
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5].
in vivo
C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05)[1].
IC 50
HIV-1; NF-κB; Human Endogenous Metabolite; Microbial Metabolite
References
[1] Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. DOI:10.1002/biof.5520270114
[2] Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. DOI:10.18632/oncotarget.24343
[3] Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217. DOI:10.1016/j.jnutbio.2014.06.001
[4] Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139. DOI:10.1038/s41598-020-64004-5
[5] Liu J, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir, 2022.
Sodium thioctate Preparation Products And Raw materials
Raw materials
Preparation Products
Sodium thioctate Suppliers
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View Lastest Price from Sodium thioctate manufacturers
- Product
- Sodium thioctate 2319-84-8
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-25
- Product
- Sodium thioctate 2319-84-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.9%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- Sodium thioctate 2319-84-8
- Price
- US $2.00/kg
- Min. Order
- 10kg
- Purity
- ask
- Supply Ability
- ask
- Release date
- 2018-12-17