PFK-158

ChemicalBook > CAS DataBase List > PFK-158

Product Name: PFK-158
CAS No.: 1462249-75-7
Chemical Name: PFK-158
Synonyms: PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
CBNumber: CB43034954
Molecular Formula: C18H11F3N2O
Formula Weight: 328.29
MOL File: 1462249-75-7.mol

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PFK-158 Property

Boiling point:: 466.3±45.0 °C(Predicted)
Density: 1.346±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form: A crystalline solid
pka: 2.46±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3145
Product name: PFK-158
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $86.8
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML3145
Product name: PFK-158
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $280
Updated: 2023/06/20

Cayman Chemical

Product number: 22987
Product name: PFK158
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 22987
Product name: PFK158
Purity: ≥95%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 22987
Product name: PFK158
Purity: ≥95%
Packaging: 25mg
Price: $220
Updated: 2024/03/01

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PFK-158 Chemical Properties,Usage,Production

Description

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC₅₀ = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC₅₀s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC₅₀ = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.

PFK-158 Preparation Products And Raw materials

Raw materials

Preparation Products

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1462249-75-7, PFK-158Related Search:

PFK-015 Silver

PFK-158

PFK-158, ACT-PFK-158

(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one

PFK-158;PFK 158

PFK-158 free base

2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-

(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one

p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3

(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one

1462249-75-7

1462249-75-1

C18H11F3N2O