PFK-015

Product Name: PFK-015
CAS No.: 4382-63-2
Chemical Name: PFK-015
Synonyms: CS-1317;PFK-015;PFK15 (PFK-015);PFK015;PFK15;PFK 15;PFK-15;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;(E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15
CBNumber: CB72705092
Molecular Formula: C17H12N2O
Formula Weight: 260.29
MOL File: 4382-63-2.mol

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PFK-015 Property

Boiling point:: 464.4±45.0 °C(Predicted)
Density: 1.237±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 3.11±0.61(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1009
Product name: PFK15
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1009
Product name: PFK15
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Cayman Chemical

Product number: 17689
Product name: PFK15
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17689
Product name: PFK15
Purity: ≥95%
Packaging: 10mg
Price: $75
Updated: 2024/03/01

Cayman Chemical

Product number: 17689
Product name: PFK15
Purity: ≥95%
Packaging: 25mg
Price: $165
Updated: 2024/03/01

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PFK-015 Chemical Properties,Usage,Production

Description

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

Uses

PFK 15 is a novel inhibitor of glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). It suppresses the glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and induces apoptosis in abnormal cells.

storage

Store at -20°C

References

1) Clem?et al.?(2013),?Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer; Mol. Cancer Ther.?12?1461 2) Zhu?et al. (2016),?PFK15,a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer; PLoS One?11?e0163768 3) Li?et al. (2017),?Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma; J. Exp. Clin. Cancer Res.?36?7

PFK-015 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFK-015 Suppliers

China 88 India 1 United Kingdom 2 United States 12 Global 103

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Shanghai Run-Biotech Co., Ltd.

Tel: 021-57171705 13817537615
Fax: QQ3095748324
Email: sales@run-biotech.com
Country: China
ProdList: 2426
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5806
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

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View Lastest Price from PFK-015 manufacturers

Career Henan Chemical Co

Product: PFK-015 4382-63-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

4382-63-2, PFK-015Related Search:

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PFK015;PFK15;PFK 15;PFK-15

CS-1317

2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15

1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one

PFK15 (PFK-015)

PFK-015

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

(E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one

4382-63-2

Inhibitors