ChemicalBook > CAS DataBase List > PFK-158
PFK-158
- Product Name
- PFK-158
- CAS No.
- 1462249-75-7
- Chemical Name
- PFK-158
- Synonyms
- PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
- CBNumber
- CB43034954
- Molecular Formula
- C18H11F3N2O
- Formula Weight
- 328.29
- MOL File
- 1462249-75-7.mol
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PFK-158 Property
- Boiling point:
- 466.3±45.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
- form
- A crystalline solid
- pka
- 2.46±0.10(Predicted)
- color
- White to light yellow
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3145
- Product name
- PFK-158
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $86.8
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SML3145
- Product name
- PFK-158
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $280
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 22987
- Product name
- PFK158
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22987
- Product name
- PFK158
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22987
- Product name
- PFK158
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $220
- Updated
- 2024/03/01
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PFK-158 Chemical Properties,Usage,Production
Description
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.
PFK-158 Preparation Products And Raw materials
Raw materials
Preparation Products
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PFK-158 Suppliers
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