ChemicalBook > CAS DataBase List > CNX-1351

CNX-1351

Product Name
CNX-1351
CAS No.
1276105-89-5
Chemical Name
CNX-1351
Synonyms
CS-1069;CNX-1351;CNX1351cas;CNX-1351, >=98%;CNX-1351; CNX 1351; CNX1351;CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351;1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione;5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
CBNumber
CB12668207
Molecular Formula
C30H35N7O3S
Formula Weight
573.71
MOL File
1276105-89-5.mol
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CNX-1351 Property

Density 
1.328±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic)
form 
Powder
pka
12.22±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
25mg
Price
$442
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
10mg
Price
$213
Updated
2024/03/01
ChemScene
Product number
CS-3610
Product name
CNX-1351
Purity
99.88%
Packaging
10mg
Price
$240
Updated
2021/12/16
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CNX-1351 Chemical Properties,Usage,Production

Biological Activity

CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.

in vivo

CNX-1351 inhibits p-Akt Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).

target

PI3Kα

6.8 nM (IC 50 )

PI3Kβ

166 nM (IC 50 )

PI3Kδ

240.3 nM (IC 50 )

PI3Kγ

3020 nM ( IC 50 )

CNX-1351 Preparation Products And Raw materials

Raw materials

Preparation Products

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CNX-1351 Suppliers

China 53 United States 9 Global 62
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
Advantage
55
Shanghai Chiral bio-compound co., Ltd.
Tel
021-5068 3667/17749785980/1029026415; 17749785980
Fax
021-50683667
Email
1029026415@qq.com
Country
China
ProdList
3013
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58

1276105-89-5, CNX-1351Related Search:

Y16 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 Mutant IDH1 inhibitor

  • 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
  • CNX-1351, >=98%
  • CNX-1351
  • 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione
  • 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
  • CS-1069
  • CNX-1351; CNX 1351; CNX1351
  • CNX1351cas
  • CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351
  • 5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-
  • 1276105-89-5
  • C30H35N7O3S
  • Inhibitors