ChemicalBook > CAS DataBase List > CNX-1351

CNX-1351

Product Name
CNX-1351
CAS No.
1276105-89-5
Chemical Name
CNX-1351
Synonyms
CS-1069;CNX-1351;CNX1351cas;CNX-1351, >=98%;CNX-1351; CNX 1351; CNX1351;CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351;1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione;5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
CBNumber
CB12668207
Molecular Formula
C30H35N7O3S
Formula Weight
573.71
MOL File
1276105-89-5.mol
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CNX-1351 Property

Density 
1.328±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic)
form 
Powder
pka
12.22±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
25mg
Price
$442
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
10mg
Price
$213
Updated
2024/03/01
ChemScene
Product number
CS-3610
Product name
CNX-1351
Purity
99.88%
Packaging
10mg
Price
$240
Updated
2021/12/16
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CNX-1351 Chemical Properties,Usage,Production

Uses

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6.8 nM.

Biological Activity

CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.

in vivo

CNX-1351 inhibits p-Akt Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).

target

PI3Kα

6.8 nM (IC 50 )

PI3Kβ

166 nM (IC 50 )

PI3Kδ

240.3 nM (IC 50 )

PI3Kγ

3020 nM ( IC 50 )

IC 50

PI3Kα: 6.8 nM (IC50); PI3Kβ: 166 nM (IC50); PI3Kδ: 240.3 nM (IC50); PI3Kγ: 3020 nM (IC50)

References

[1] Nacht M, et al. Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα. J Med Chem. 2013 Feb 14;56(3):712-21. DOI:10.1021/jm3008745

CNX-1351 Preparation Products And Raw materials

Raw materials

Preparation Products

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CNX-1351 Suppliers

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1276105-89-5, CNX-1351Related Search:

Y16 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 Mutant IDH1 inhibitor

  • 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
  • CNX-1351, >=98%
  • CNX-1351
  • 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione
  • 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
  • CS-1069
  • CNX-1351; CNX 1351; CNX1351
  • CNX1351cas
  • CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351
  • 5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-
  • 1276105-89-5
  • C30H35N7O3S
  • Inhibitors