CNX-1351

ChemicalBook > CAS DataBase List > CNX-1351

Product Name: CNX-1351
CAS No.: 1276105-89-5
Chemical Name: CNX-1351
Synonyms: CS-1069;CNX-1351;CNX1351cas;CNX-1351, >=98%;CNX-1351; CNX 1351; CNX1351;CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351;1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione;5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
CBNumber: CB12668207
Molecular Formula: C30H35N7O3S
Formula Weight: 573.71
MOL File: 1276105-89-5.mol

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CNX-1351 Property

Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic)
form: Powder
pka: 12.22±0.40(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30264
Product name: CNX-1351
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 30264
Product name: CNX-1351
Packaging: 25mg
Price: $442
Updated: 2024/03/01

Cayman Chemical

Product number: 30264
Product name: CNX-1351
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 30264
Product name: CNX-1351
Packaging: 10mg
Price: $213
Updated: 2024/03/01

ChemScene

Product number: CS-3610
Product name: CNX-1351
Purity: 99.88%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

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CNX-1351 Chemical Properties,Usage,Production

Biological Activity

CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.

in vivo

CNX-1351 inhibits p-Akt ^Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).

target

PI3Kα

6.8 nM (IC ₅₀ )

PI3Kβ

166 nM (IC ₅₀ )

PI3Kδ

240.3 nM (IC ₅₀ )

PI3Kγ

3020 nM ( IC ₅₀ )

CNX-1351 Preparation Products And Raw materials

Raw materials

Preparation Products

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CNX-1351 Suppliers

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1276105-89-5, CNX-1351Related Search:

Y16 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 Mutant IDH1 inhibitor

1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351

CNX-1351, >=98%

CNX-1351

1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione

1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione

CS-1069

CNX-1351; CNX 1351; CNX1351

CNX1351cas

CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351

5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-

1276105-89-5

C30H35N7O3S

Inhibitors