LY 303511 (hydrochloride)

Product Name: LY 303511 (hydrochloride)
CAS No.: 2070014-90-1
Chemical Name: LY 303511 (hydrochloride)
Synonyms: CS-1207;LY 303511 (hydrochloride);LY 303511 hydrochloride, 10 mM in DMSO;8-Phenyl-2-(piperazin-1-yl)-4H-chromen-4-one hydrochloride;TNFR,LY-303511,TNF Receptor,inhibit,LY 303511,LY 303511 hydrochloride,Tumor Necrosis Factor Receptor,Inhibitor,Potassium Channel,LY303511,KcsA
CBNumber: CB72715646
Molecular Formula: C19H19ClN2O2
Formula Weight: 342.82
MOL File: 2070014-90-1.mol

More

Less

LY 303511 (hydrochloride) Property

storage temp.: Inert atmosphere,Room Temperature
form: Solid
color: White to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-3206
Product name: LY303511hydrochloride
Purity: 98.78%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-3206
Product name: LY303511hydrochloride
Purity: 98.78%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 1529DY
Product name: LY303511hydrochloride
Packaging: 50mg
Price: $201
Updated: 2021/12/16

ChemScene

Product number: CS-3206
Product name: LY303511hydrochloride
Purity: 98.78%
Packaging: 50mg
Price: $804
Updated: 2021/12/16

CSNpharm

Product number: CSN19147
Product name: LY303511HCl
Packaging: 1mg
Price: $50
Updated: 2021/12/16

More

Less

LY 303511 (hydrochloride) Chemical Properties,Usage,Production

Uses

LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.

in vivo

Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm³, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo^[4].

References

[1] Bodenstine TM, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70(23):10002-11. DOI:10.1158/0008-5472.CAN-10-2606
[2] El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 2003 Apr;17(6):720-2. DOI:10.1096/fj.02-0802fje
[3] Shenoy K, et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 2009 Mar 1;69(5):1941-50. DOI:10.1158/0008-5472.CAN-08-1996
[4] Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J Pharmacol E DOI:10.1124/jpet.105.083550

LY 303511 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LY 303511 (hydrochloride) Suppliers

China 41 India 1 United States 6 Global 48

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3276
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

2070014-90-1, LY 303511 (hydrochloride)Related Search:

Y16 TENOVIN-1 PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 CNX-1351 Mutant IDH1 inhibitor

LY 303511 (hydrochloride)

CS-1207

8-Phenyl-2-(piperazin-1-yl)-4H-chromen-4-one hydrochloride

TNFR,LY-303511,TNF Receptor,inhibit,LY 303511,LY 303511 hydrochloride,Tumor Necrosis Factor Receptor,Inhibitor,Potassium Channel,LY303511,KcsA

LY 303511 hydrochloride, 10 mM in DMSO

2070014-90-1