LY 303511 (hydrochloride)
- Product Name
- LY 303511 (hydrochloride)
- CAS No.
- 2070014-90-1
- Chemical Name
- LY 303511 (hydrochloride)
- Synonyms
- CS-1207;LY 303511 (hydrochloride);LY 303511 hydrochloride, 10 mM in DMSO;8-Phenyl-2-(piperazin-1-yl)-4H-chromen-4-one hydrochloride;TNFR,LY-303511,TNF Receptor,inhibit,LY 303511,LY 303511 hydrochloride,Tumor Necrosis Factor Receptor,Inhibitor,Potassium Channel,LY303511,KcsA
- CBNumber
- CB72715646
- Molecular Formula
- C19H19ClN2O2
- Formula Weight
- 342.82
- MOL File
- 2070014-90-1.mol
LY 303511 (hydrochloride) Property
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- CS-3206
- Product name
- LY303511hydrochloride
- Purity
- 98.78%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 1529DY
- Product name
- LY303511hydrochloride
- Packaging
- 50mg
- Price
- $201
- Updated
- 2021/12/16
- Product number
- CS-3206
- Product name
- LY303511hydrochloride
- Purity
- 98.78%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-3206
- Product name
- LY303511hydrochloride
- Purity
- 98.78%
- Packaging
- 50mg
- Price
- $804
- Updated
- 2021/12/16
- Product number
- A182423
- Product name
- LY303511Hydrochloride
- Purity
- 98+%
- Packaging
- 1g
- Price
- $7055
- Updated
- 2021/12/16
LY 303511 (hydrochloride) Chemical Properties,Usage,Production
Uses
LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.
in vivo
Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm3, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo[4].
References
[1] Bodenstine TM, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70(23):10002-11. DOI:10.1158/0008-5472.CAN-10-2606
[2] El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 2003 Apr;17(6):720-2. DOI:10.1096/fj.02-0802fje
[3] Shenoy K, et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 2009 Mar 1;69(5):1941-50. DOI:10.1158/0008-5472.CAN-08-1996
[4] Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J Pharmacol E DOI:10.1124/jpet.105.083550
LY 303511 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
LY 303511 (hydrochloride) Suppliers
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29759
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3277
- Advantage
- 58
- Tel
- 021-021-61998551 13122364865
- sale1@shzysw.net
- Country
- China
- ProdList
- 9778
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9208
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4494
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 9898
- Advantage
- 58
- Tel
- 0512-65118909 18100677375
- sales@szzxbio.com
- Country
- China
- ProdList
- 2993
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9835
- Advantage
- 58
- Tel
- 400-821-026
- Sales@sangon.com
- Country
- China
- ProdList
- 6710
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- +86-057181025280; +8617767106207
- Fax
- 0571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 49734
- Advantage
- 58
- Tel
- 18617181553
- Country
- CHINA
- ProdList
- 112
- Advantage
- 58
- Tel
- 15571990006
- Country
- CHINA
- ProdList
- 122
- Advantage
- 58
- Tel
- 15017560539
- Country
- CHINA
- ProdList
- 142
- Advantage
- 58
- Tel
- 13729876931
- Country
- CHINA
- ProdList
- 183
- Advantage
- 58
- Tel
- 15571990006
- Country
- CHINA
- ProdList
- 141
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- Proteintech-CN@ptglab.com
- Country
- CHINA
- ProdList
- 6290
- Advantage
- 58
- Tel
- --
- Fax
- --
- prbiological@sohu.com
- Country
- CHINA
- ProdList
- 6976
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@shrbio.com
- Country
- CHINA
- ProdList
- 6666
- Advantage
- 58
- Tel
- --
- Fax
- --
- jingkehuaxue@163.com
- Country
- CHINA
- ProdList
- 6141
- Advantage
- 58
- Tel
- --
- Fax
- --
- 570202610@qq.com
- Country
- CHINA
- ProdList
- 6851
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1914109725@qq.com
- Country
- CHINA
- ProdList
- 6518
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2801747566@qq.com
- Country
- CHINA
- ProdList
- 4902
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58