ChemicalBook > CAS DataBase List > Y16

Y16

Product Name
Y16
CAS No.
429653-73-6
Chemical Name
Y16
Synonyms
Y16;Y16, >98%;Y16, 429653-73-6;Inhibitor,inhibit,Y-16,Y 16,Ras,Y16;4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione;4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione;3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-
CBNumber
CB92735545
Molecular Formula
C24H20N2O3
Formula Weight
384.43
MOL File
429653-73-6.mol
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Y16 Property

Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
8.84±0.20(Predicted)
form 
powder
color 
, faint yellow to dark orange
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0873
Product name
Y16
Purity
≥98% (HPLC)
Packaging
25mg
Price
$42.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0873
Product name
Y16
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
ChemScene
Product number
CS-3879
Product name
Y16
Purity
99.03%
Packaging
5mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-3879
Product name
Y16
Purity
99.03%
Packaging
10mg
Price
$144
Updated
2021/12/16
Crysdot
Product number
CD31001921
Product name
Y16
Purity
98+%
Packaging
5mg
Price
$49
Updated
2021/12/16
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Y16 Chemical Properties,Usage,Production

Biological Activity

Y16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.

in vitro

Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.

Cell Viability Assay

Cell Line: NIH 3T3 cells
Concentration: 10 μΜ, 30 μΜ
Incubation Time: 24 hours
Result: Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.

Western Blot Analysis

Cell Line: NIH 3T3 cells
Concentration: 10 μΜ, 30 μΜ
Incubation Time: 24 hours
Result: Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.

target

Y16 Preparation Products And Raw materials

Raw materials

Preparation Products

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Y16 Suppliers

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021-58950125
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429653-73-6, Y16Related Search:


  • Y16
  • 4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
  • Y16, >98%
  • Y16, 429653-73-6
  • 3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-
  • Inhibitor,inhibit,Y-16,Y 16,Ras,Y16
  • 4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione
  • 429653-73-6
  • TargetValue
    RhoGEFs
    ()