ChemicalBook > CAS DataBase List > 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

Product Name
1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE
CAS No.
4506-66-5
Chemical Name
1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE
Synonyms
1,2,4,5-Benzenetetraamine tetrahydrochloride;Benzene-1,2,4,5-tetraamine tetrahydrochloride;Y15;FAK Inhibitor 14;1,2,4,5-TETRAAMINOBENZENE TETRAHYDROCHLORIDE;Y-15;NSC 667249;FAK inhibitor Y15;Y15 tetrahydrochloride;Benzene-1,2,4,5-tetrayL
CBNumber
CB4137959
Molecular Formula
C6H11ClN4
Formula Weight
174.63
MOL File
4506-66-5.mol
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1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Property

Melting point:
≥300 °C(lit.)
storage temp. 
room temp
solubility 
H2O: soluble20mg/mL, clear
form 
powder
color 
, faint purple to dark brown
BRN 
3701344
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey
BZDGCIJWPWHAOF-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
305065
Product name
1,2,4,5-Benzenetetramine tetrahydrochloride
Purity
technical grade
Packaging
1g
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
305065
Product name
1,2,4,5-Benzenetetramine tetrahydrochloride
Purity
technical grade
Packaging
5g
Price
$382
Updated
2024/03/01
Cayman Chemical
Product number
14485
Product name
FAK Inhibitor 14
Purity
≥95%
Packaging
10mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
14485
Product name
FAK Inhibitor 14
Purity
≥95%
Packaging
25mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0837
Product name
FAK Inhibitor 14
Purity
≥95% (HPLC)
Packaging
10mg
Price
$44.16
Updated
2024/03/01
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1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Chemical Properties,Usage,Production

Description

FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-R.1 Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo. Induces regression of pancreatic tumors2 and glioblastoma3. Displays antiangiogenic activity.4

Uses

FAK Inhibitor 14 directly blocks phosphorylation of focal adhesion kinase (FAK) in a dose- and time-dependent manner and has also shown breast tumor regression in vivo. It has been suggested that targeting the Y397 site of FAK with FAK Inhibitor 14 can be effectively used in cancer therapy.

Uses

FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.

General Description

A cell-permeable tetraamine compound that is identified from a computer-aided molecular docking screening based on Fak Y397 interaction and is shown to inhibit FAK (Cat. No. 324876) autophosphorylation as well as its kinase activity toward paxillin phosphorylation both in cell-free kinase assays (IC50<1 μM) and in BT474 breast cancer cultures, while exhibiting little activity against Pyk2 (Cat. No. 662067) autophosphorylation or the kinase activity of c-Raf, c-Src, EGFR, VEGFR-3, IGF-1, Met, PDGFR-α, Pyk2, and PI 3-K (p110δ/p85α). Reported to inhibit BT474 proliferation both in cultures in vitro (IC50 ~10 μM) and in mice in vivo (~25% of no treatment controls on day 23; 30 mg/kg via 5 i.p/wk).

Biological Activity

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC 50 = 1 μ M), promotes cell detachment and inhibits cell adhesion in vitro . Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo .

Biochem/physiol Actions

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.

storage

Desiccate at RT

References

1) Golubovskaya et al. (2008), A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth; J. Med. Chem., 51 7405 2) Hochwald et al. (2009), A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer; Cell Cycle, 8 2435 3) Golubovskaya et al. (2013), Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide; Mol. Cancer Ther., 12 162 4) Cabrita et al. (2011), Focal Adhesion kinase inhibitors are potent anti-angiogenic agents; Mol. Oncol., 5 517

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Suppliers

China 163 France 1 Germany 1 India 1 Switzerland 1 United Kingdom 3 United States 26 Global 196
Harbin kayMeiKe Chemical Co., Ltd.
Tel
13945082518
Fax
0451-86609001
Email
niulizhongnlz@126.com
Country
China
ProdList
10
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64
Nanjing Thander New Material Science & Technology Co., Ltd
Tel
15384069853
Email
2048571647@qq.com
Country
China
ProdList
344
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
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Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9552
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VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
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Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
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View Lastest Price from 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE 4506-66-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-24
Hebei Guanlang Biotechnology Co., Ltd.
Product
1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE 4506-66-5
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-04-27
Henan Aochuang Chemical Co.,Ltd.
Product
1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE 4506-66-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-30

4506-66-5, 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDERelated Search:

Apigenin CASTANOSPERMINE Bortezomib Sunitinib Malate Methylamine hydrochloride Y16 Y 11 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE p-Phenylenediamine dihydrochloride Benzene-1,3-diamine dihydrochloride OPD EASY-tablets 1,2,4-Benzenetriamine dihydrochloride

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  • tetraamine tetrahydrochL
  • 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE ISO 9001：2015 REACH
  • 5-BENZENETETRAMINE TETRAHYDROCHLORIDE
  • Y15 tetrahydrochloride
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  • 4506-66-5
  • C6H14N44Cl
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  • Organic Building Blocks
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  • Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI.