1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

ChemicalBook > CAS DataBase List > 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

Product Name: 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE
CAS No.: 4506-66-5
Chemical Name: 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE
Synonyms: 1,2,4,5-Benzenetetraamine tetrahydrochloride;Benzene-1,2,4,5-tetraamine tetrahydrochloride;Y15;FAK Inhibitor 14;1,2,4,5-TETRAAMINOBENZENE TETRAHYDROCHLORIDE;Y-15;NSC 667249;FAK inhibitor Y15;Y15 tetrahydrochloride;Benzene-1,2,4,5-tetrayL
CBNumber: CB4137959
Molecular Formula: C6H11ClN4
Formula Weight: 174.63
MOL File: 4506-66-5.mol

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1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Property

Melting point:: ≥300 °C(lit.)
storage temp.: room temp
solubility: H2O: soluble20mg/mL, clear
form: powder
color: , faint purple to dark brown
BRN: 3701344
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey: BZDGCIJWPWHAOF-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 305065
Product name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Purity: technical grade
Packaging: 1g
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: 305065
Product name: 1,2,4,5-Benzenetetramine tetrahydrochloride
Purity: technical grade
Packaging: 5g
Price: $382
Updated: 2024/03/01

Cayman Chemical

Product number: 14485
Product name: FAK Inhibitor 14
Purity: ≥95%
Packaging: 10mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 14485
Product name: FAK Inhibitor 14
Purity: ≥95%
Packaging: 25mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0837
Product name: FAK Inhibitor 14
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $44.16
Updated: 2024/03/01

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1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Chemical Properties,Usage,Production

Description

FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-R.1 Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo. Induces regression of pancreatic tumors2 and glioblastoma3. Displays antiangiogenic activity.4

Uses

FAK Inhibitor 14 directly blocks phosphorylation of focal adhesion kinase (FAK) in a dose- and time-dependent manner and has also shown breast tumor regression in vivo. It has been suggested that targeting the Y397 site of FAK with FAK Inhibitor 14 can be effectively used in cancer therapy.

Uses

FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.

General Description

A cell-permeable tetraamine compound that is identified from a computer-aided molecular docking screening based on Fak Y397 interaction and is shown to inhibit FAK (Cat. No. 324876) autophosphorylation as well as its kinase activity toward paxillin phosphorylation both in cell-free kinase assays (IC₅₀<1 μM) and in BT474 breast cancer cultures, while exhibiting little activity against Pyk2 (Cat. No. 662067) autophosphorylation or the kinase activity of c-Raf, c-Src, EGFR, VEGFR-3, IGF-1, Met, PDGFR-α, Pyk2, and PI 3-K (p110δ/p85α). Reported to inhibit BT474 proliferation both in cultures in vitro (IC₅₀ ~10 μM) and in mice in vivo (~25% of no treatment controls on day 23; 30 mg/kg via 5 i.p/wk).

Biological Activity

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC 50 = 1 μ M), promotes cell detachment and inhibits cell adhesion in vitro . Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo .

Biochem/physiol Actions

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.

storage

Desiccate at RT

References

1) Golubovskaya et al. (2008), A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth; J. Med. Chem., 51 7405 2) Hochwald et al. (2009), A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer; Cell Cycle, 8 2435 3) Golubovskaya et al. (2013), Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide; Mol. Cancer Ther., 12 162 4) Cabrita et al. (2011), Focal Adhesion kinase inhibitors are potent anti-angiogenic agents; Mol. Oncol., 5 517

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE 4506-66-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-24

Hebei Guanlang Biotechnology Co., Ltd.

Product: 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE 4506-66-5
Price: US $10.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-04-27

Henan Aochuang Chemical Co.,Ltd.

Product: 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE 4506-66-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-30

4506-66-5, 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDERelated Search:

Apigenin CASTANOSPERMINE Bortezomib Sunitinib Malate Methylamine hydrochloride Y16 Y 11 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE p-Phenylenediamine dihydrochloride Benzene-1,3-diamine dihydrochloride OPD EASY-tablets 1,2,4-Benzenetriamine dihydrochloride

1,2,4,5-TETRAAMINOBENZENE TETRAHYDROCHLORIDE

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

1,2,4,5-Benzenetetraamine tetrahydrochloride

benzene-1,2,4,5-tetrayltetraamine tetrahydrochloride

1,2,4,5-BENZENETETRAMINE TETRAHYDRO-CHLO RIDE, TECH.

1,2,4,5-BenzenetetraminetetraHCl

1,2,4,5-Benzenetetramine tetrahydrochloride, 1,2,4,5-Tetraaminobenzene tetrahydrochloride

(2,4,5-triaminophenyl)amine tetrahydrochloride

benzene-1,2,4,5-tetramine tetrahydrochloride

FAK Inhibitor 14

1,2,4,5-Benzenetetramine tetrahydrochloride ,98%

1,2,4,5-Benzenetetramine tetrahydrochloride,1,2,4,5-Benzenetetramine tetrahydrochloride, 1,2,4,5-Tetraaminobenzene tetrahydrochloride

Benzene-1,2,4,5-tetraamine tetrahydrochloride

Benzene-1,2,4,5-tetraMine 4HCl

FAK inhibitor Y15

Y15

Y-15

1,2,4,5-BenzenetetraMine tetrahydrochloride technical grade

1,2,4,5-Benzenetetraamine 4HCl

NSC 667249

Focal Adhesion Kinase Inhibitor I

1;2;4;5-TETRAAMINOBENZENE TETRA HYDROCHLORIDE;FAK INHIBITOR Y15;Y15

5-tetraaminobenzene tetra hydrochloride

Benzol-1,2,4,5-tetramintetrahydrochlorid

FAK INHIBITOR Y15;Y-15;FAK INHIBITOR 14

Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

1,2,4,5-Benzenetetramine tetrahydrochlor

Benzene-1,2,4,5-tetrayL

tetraamine tetrahydrochL

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE ISO 9001：2015 REACH

5-BENZENETETRAMINE TETRAHYDROCHLORIDE

Y15 tetrahydrochloride

benzene-1,2,4,5-tetraamine hydrochloride

1,2,4,5-Benzenetetramine tetrahydrochloride (Y15), 97%

1,2,4,5-phenylenetetramine tetrahydrochloride

1,2,4, 5-phenyltetramine tetramine hydrochloride

4506-66-5

C6H14N44Cl

C6H14Cl4N4

C6H2NH244HCl

C6H10N44HCl

C6H10N44ClH

Organic Building Blocks

Nitrogen Compounds

Building Blocks

Amine Salts

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI.