ChemicalBook > CAS DataBase List > PFK-015

PFK-015

Product Name
PFK-015
CAS No.
4382-63-2
Chemical Name
PFK-015
Synonyms
CS-1317;PFK-015;PFK15 (PFK-015);PFK015;PFK15;PFK 15;PFK-15;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;(E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15
CBNumber
CB72705092
Molecular Formula
C17H12N2O
Formula Weight
260.29
MOL File
4382-63-2.mol
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PFK-015 Property

Boiling point:
464.4±45.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
3.11±0.61(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1009
Product name
PFK15
Purity
≥98% (HPLC)
Packaging
5mg
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1009
Product name
PFK15
Purity
≥98% (HPLC)
Packaging
25mg
Price
$476
Updated
2024/03/01
Cayman Chemical
Product number
17689
Product name
PFK15
Purity
≥95%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17689
Product name
PFK15
Purity
≥95%
Packaging
10mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
17689
Product name
PFK15
Purity
≥95%
Packaging
25mg
Price
$165
Updated
2024/03/01
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PFK-015 Chemical Properties,Usage,Production

Description

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

Uses

PFK 15 is a novel inhibitor of glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). It suppresses the glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and induces apoptosis in abnormal cells.

storage

Store at -20°C

References

1) Clem?et al.?(2013),?Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer; Mol. Cancer Ther.?12?1461 2) Zhu?et al. (2016),?PFK15,a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer; PLoS One?11?e0163768 3) Li?et al. (2017),?Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma; J. Exp. Clin. Cancer Res.?36?7

PFK-015 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFK-015 Suppliers

China 87 India 1 United Kingdom 2 United States 12 Global 102
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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View Lastest Price from PFK-015 manufacturers

Career Henan Chemical Co
Product
PFK-015 4382-63-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

4382-63-2, PFK-015Related Search:

PFK-158 Y16 TENOVIN-1 LY 303511 (hydrochloride) CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 CNX-1351 Mutant IDH1 inhibitor Pioglitazone BML-275 AVP-AEW541 Trametinib A 769662 Phenformin hydrochloride

  • PFK015;PFK15;PFK 15;PFK-15
  • CS-1317
  • 2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-
  • 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15
  • 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one
  • PFK15 (PFK-015)
  • PFK-015
  • 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
  • (E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one
  • 4382-63-2
  • Inhibitors