Palvanil Chemical Properties,Usage,Production
Uses
Palvanil is a Capsaicin.html" class="link-product" target="_blank">Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[1][2].
in vivo
Palvanil (subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect[2].
Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation[2].
Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia in spared nerve injury (SNI) mice[2].
| Animal Model: | Male CD-1 mice[2] |
| Dosage: | 1 or 10 mg/kg |
| Administration: | Subcutaneous injection; 1 or 10 mg/kg; once |
| Result: | Led to a slight and short lasting hypothermic effect, produced late hyperthermia. |
| Animal Model: | Female BALB/C mice[2] |
| Dosage: | 100 μL (15 nM) per mouse |
| Administration: | Intraperitoneal injection; 100 μL (15 nM) per mouse; once |
| Result: | Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s). |
| Animal Model: | Male CD-1 mice received formalin[2] |
| Dosage: | 0.5, 0.75, and 1 mg/kg |
| Administration: | Intravenous injection; 0.5, 0.75, and 1 mg/kg; once |
| Result: | Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner. |
| Animal Model: | Male C57BL/6J mice with acute inflammation induced by Carrageenan[2] |
| Dosage: | 2.5 mg/kg |
| Administration: | Intravenous injection; 2.5 mg/kg; once |
| Result: | Reduced the volume of the oedema in the ipsilateral hind paw (64%). |
| Animal Model: | Male CD-1 mice[2] |
| Dosage: | 0.5 and 1 mg/kg |
| Administration: | Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days |
| Result: | Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner. |
References
[1] Luciano De Petrocellis, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res. 2011 Apr;63(4):294-9. DOI:10.1016/j.phrs.2010.12.019
[2] Livio Luongo, et al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012 Sep;66(3):243-50. DOI:10.1016/j.phrs.2012.05.005