ChemicalBook > CAS DataBase List > 4-Iodo-5-methylpyridin-2-amine

4-Iodo-5-methylpyridin-2-amine

Product Name: 4-Iodo-5-methylpyridin-2-amine
CAS No.: 1227581-81-8
Chemical Name: 4-Iodo-5-methylpyridin-2-amine
Synonyms: 4-Iodo-5-methylpyridin-2-amine;4-Iodo-5-methyl-2-pyridinamine;2-Amino-4-Iodo-5-Methylpyridine;2-Pyridinamine, 4-iodo-5-methyl-;4-Iodo-5-methyl-pyridin-2-ylamine
CBNumber: CB43042140
Molecular Formula: C6H7IN2
Formula Weight: 234.04
MOL File: 1227581-81-8.mol

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4-Iodo-5-methylpyridin-2-amine Property

Boiling point:: 316.0±42.0 °C(Predicted)
Density: 1.898±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 6.20±0.24(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I737325
Product name: 4-Iodo-5-methylpyridin-2-amine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: AK148253
Product name: 4-Iodo-5-methylpyridin-2-amine
Purity: 97%
Packaging: 100mg
Price: $129
Updated: 2021/12/16

Ambeed

Product number: A431394
Product name: 4-Iodo-5-methylpyridin-2-amine
Purity: 97%
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Price: $176
Updated: 2021/12/16

Ambeed

Product number: A431394
Product name: 4-Iodo-5-methylpyridin-2-amine
Purity: 97%
Packaging: 1g
Price: $352
Updated: 2021/12/16

Chemenu

Product number: CM174390
Product name: 4-iodo-5-methylpyridin-2-amine
Purity: 97%
Packaging: 1g
Price: $449
Updated: 2021/12/16

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4-Iodo-5-methylpyridin-2-amine Chemical Properties,Usage,Production

Synthesis

153034-94-7

1227581-81-8

The general procedure for the synthesis of 4-iodo-5-methylpyridin-2-amine from 2-fluoro-4-iodo-5-methylpyridine was as follows: 2-fluoro-4-iodo-5-methylpyridine (3.00 g, 12.7 mmol) was mixed with concentrated aqueous ammonium hydroxide (3.5 mL, 90 mmol) in DMSO (17 mL) to form a white suspension. The reaction mixture was placed in a microwave reactor and reacted at 140 °C for 4 hours. After the reaction was completed, it was cooled to room temperature. The reaction mixture was diluted with EtOAc and water to separate the organic and aqueous layers. The aqueous layer was extracted with EtOAc (3 x 50 mL), all organic layers were combined and concentrated under reduced pressure. The concentrated residue was adsorbed onto silica gel and purified by fast silica gel chromatography with an elution gradient of 0 to 10% MeOH in DCM solution, resulting in 4-iodo-5-methylpyridin-2-amine (800 mg, 27% yield) as a white solid. The product was confirmed by 1H NMR (300 MHz, DMSO-d6, 27 °C): δ 2.13 (s, 3H), 5.81 (s, 2H), 6.99 (s, 1H), 7.75 (s, 1H). Mass spectral analysis showed m/z: ES+ [M+H]+ 235.

References

[1] Patent: US2016/376287, 2016, A1. Location in patent: Paragraph 0957
[2] Patent: WO2011/26904, 2011, A1. Location in patent: Page/Page column 131
[3] Patent: WO2012/87519, 2012, A1. Location in patent: Page/Page column 122

4-Iodo-5-methylpyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1227581-81-8, 4-Iodo-5-methylpyridin-2-amineRelated Search:

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4-Iodo-5-methyl-pyridin-2-ylamine

1227581-81-8