Closantel

Description References

Product Name: Closantel
CAS No.: 57808-65-8
Chemical Name: Closantel
Synonyms: Zycloz;Diantel;R-31520;Closante;CLOSANTEL;faskoverm;5-diiodo-y-;iodobenzamide;CLOSANTEL BASE;Cyanoliodamide
CBNumber: CB5360606
Molecular Formula: C22H14Cl2I2N2O2
Formula Weight: 663.07
MOL File: 57808-65-8.mol

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Closantel Property

Melting point:: 217.8°
Boiling point:: 590.5±50.0 °C(Predicted)
Density: 1.8759 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
pka: 5.99±0.48(Predicted)
CAS DataBase Reference: 57808-65-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 2811
WGK Germany: 3
RTECS: CV2444250
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: A veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34093
Product name: Closantel
Purity: PESTANAL
Packaging: 100mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 100mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 500mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 1g
Price: $547
Updated: 2024/03/01

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Closantel Chemical Properties,Usage,Production

Description

Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.

References

http://www.interchemie.com/veterinary-medicines/closan-50.html

Chemical Properties

White to light yellow powder

Uses

antianginal, antihypertensive

Definition

ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Closantel Preparation Products And Raw materials

Raw materials

Preparation Products

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Closantel Suppliers

Brazil 1 China 176 China Hong Kong 1 Europe 2 France 1 Germany 3 India 25 Japan 2 Switzerland 2 United Kingdom 8 United States 27 Global 248

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8073
Advantage: 58

Xunteng International Trading Co.,Limited

Tel
Country: China Hong Kong
ProdList: 878
Advantage: 55

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View Lastest Price from Closantel manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: Closantel 57808-65-8
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-08-06

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Closantel 57808-65-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-23

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Closantel 57808-65-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-07

57808-65-8, ClosantelRelated Search:

CHLOROPHOSPHONAZO III Cyhalothrin Cyhalothrin Niclosamide ethanolamine salt Niclosamide theta-Cypermethrin BETA-CYPERMETHRIN Oxyclozanide 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile 2-HYDROXY-5-IODO-BENZALDEHYDE 2-(2-Chlorophenyl)acetonitrile 3-Methylbenzyl cyanide 3,5-DIIODOSALICYLALDEHYDE Difluorochloromethane 3-Iodobenzylamine hydrochloride (4-AMINOPHENYL)PHENYLACETONITRILE HYDROCHLORIDE,97% 2-(4-aminophenyl)propiononitrile closantel sodium salt,CLOSANTEL SODIUM,CLOSANTEL(NA)

5-diiodo-y-

benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox

faskoverm

CLOSANTEL

CLOSANTEL BASE

N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE

n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid

iodobenzamide

n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di

5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE

N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE

Benzamide, N-5-chloro-4-(4-chlorophenyl)cyanomethyl-2-methylphenyl-2-hydroxy-3,5-diiodo-

5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide

CLOSANTEL(PATENT)

N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)

N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide

Diantel

N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

R-31520

Zycloz

5'-Chloro-.alpha.4-(p-chlorophenyl)-.alpha.4-cyano-3,5-diiodo-2',4'-salicyloxylidide

Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hy

Closantelfreebase

N-(5-Chloro-4-[(RS)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

Closante

Closantel Solution in Methanol/DMSO, 1000ug/mL

Cyanoliodamide

Closantel N-[5-chloor-4-[(4-chloorfenyl)-cyanomethyl]-2-methylfenyl]-2- hydroxy-3,5-di-joodbenzamide

57808-65-8

57805-65-8

C22H14Cl2I2N2O2

COREG CR