18-Methoxy-18-oxooctadecanoic acid
- Product Name
- 18-Methoxy-18-oxooctadecanoic acid
- CAS No.
- 72849-35-5
- Chemical Name
- 18-Methoxy-18-oxooctadecanoic acid
- Synonyms
- 18-methoxy-18-oxooctadeca;18-Methoxy-18-oxooctadecanoic acid;Octadecanedioic acid, 1-methyl ester;Octadecanedioic acid mono-metyl ester;octadecanedioic acid monomethyl ester;1,18-octadecanedioic acid monomethyl ester
- CBNumber
- CB43049200
- Molecular Formula
- C19H36O4
- Formula Weight
- 328.49
- MOL File
- 72849-35-5.mol
18-Methoxy-18-oxooctadecanoic acid Property
- Melting point:
- 72-74 °C
- Boiling point:
- 439.8±18.0 °C(Predicted)
- Density
- 0.965±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- pka
- 4.78±0.10(Predicted)
- InChI
- InChI=1S/C19H36O4/c1-23-19(22)17-15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18(20)21/h2-17H2,1H3,(H,20,21)
- InChIKey
- RHRXFESGFLYUHB-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)CCCCCCCCCCCCCCCCC(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9773CB
- Product name
- 18-Methoxy-18-oxooctadecanoicacid
- Packaging
- 250mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- A1490302
- Product name
- 18-Methoxy-18-oxooctadecanoicacid
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- A258335
- Product name
- 18-Methoxy-18-oxooctadecanoicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- A258335
- Product name
- 18-Methoxy-18-oxooctadecanoicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- A1490302
- Product name
- 18-Methoxy-18-oxooctadecanoicacid
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $56
- Updated
- 2021/12/16
18-Methoxy-18-oxooctadecanoic acid Chemical Properties,Usage,Production
Uses
18-Methoxy-18-oxooctadecanoic acid is a long alkane linker with a terminal carboxylic acid group. The terminal carboxylic acid group can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
Synthesis
1472-93-1
72849-35-5
The general procedure for the synthesis of monomethyl octadecanedioate from dimethyl octadecanedioate was as follows: compound 8 (5.8 mmol) was added to 0.07 M Ba(OH) solution in anhydrous methanol (85 mL) and the reaction mixture was stirred at 40 °C for 24 hours. After completion of the reaction, the mixture was filtered under reduced pressure. The resulting precipitate was washed with ether and dissolved in deionized water. Subsequently, the solution was acidified to pH 3 with hydrochloric acid and extracted twice with dichloromethane. The organic phases were combined, the solvents were removed by vacuum evaporation and the resulting residue was purified by fast column chromatography using petroleum ether:ethyl acetate (8:2, v/v) as eluent to give the final compound 9 in 52% yield.
References
[1] Journal of Lipid Research, 2015, vol. 56, # 1, p. 129 - 141
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1979, vol. 17B, p. 396
18-Methoxy-18-oxooctadecanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 18-Methoxy-18-oxooctadecanoic acid manufacturers
- Product
- Octadecanedioic acid, 1-methyl ester 72849-35-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-03-05