Elafibranor(GFT505)

ChemicalBook > CAS DataBase List > Elafibranor(GFT505)

Product Name: Elafibranor(GFT505)
CAS No.: 923978-27-2
Chemical Name: Elafibranor(GFT505)
Synonyms: CS-2411;SureCN815512;elafibranor E;Elafibranor(GFT505);GFT505(ELAFIBRANOR);GFT505; GFT-505; GFT 505;;Elafibranor (GFT-505, Ph III);ELAFIBRANOR;GF T505;GFT-505;GFT505;Elafibranor(GFT505) ISO 9001：2015 REACH;Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-
CBNumber: CB43049684
Molecular Formula: C22H24O4S
Formula Weight: 384.49
MOL File: 923978-27-2.mol

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Elafibranor(GFT505) Property

Boiling point:: 569.0±50.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to at least 25 mg/ml).
form: solid
pka: 3.30±0.11(Predicted)
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23508
Product name: Elafibranor
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23508
Product name: Elafibranor
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 23508
Product name: Elafibranor
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

TRC

Product number: G368870
Product name: GFT-505
Packaging: 25mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-5522
Product name: Elafibranor
Purity: 99.18%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

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Elafibranor(GFT505) Chemical Properties,Usage,Production

Description

Elafibranor is an agonist of the peroxisome proliferator-activated receptors (PPAR) α and δ. It increases HDL secretion and expression of the lipid-related genes ABCA1, PLIN2, and ABHD5 in Caco-2/TC7 cells in a PPARα-dependent manner. Elafibranor (10 mg/kg) decreases levels of plasma triglycerides and total cholesterol while increasing plasma HDL and expression of Acox1, a PPARα target gene, in the liver of ApoE2-KI wild-type, but not PPARα knockout, mice fed a Western diet. However, PPARα knockout mice exhibit a decrease in plasma total and non-HDL cholesterol levels, indicating PPARδ has a role in these functions. Elafibranor (30 mg/kg) reduces diet-induced macro- and micro-steatosis in a PPARα-deficient mouse model of non-alcoholic steatohepatitis. It also reduces cholesterol and triglyceride accumulation as well as macrovesicular steatosis in the liver of insulin-resistant db/db mice fed the methionine-choline deficient (MCD) diet. Formulations containing elafibranor are under clinical investigation for the treatment of non-alcoholic steatohepatitis.

Uses

GFT-505 is a?dual?PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.

Biological Functions

Elafibranor (GFT505) is an agonist of peroxisome proliferator-activated receptor (PPAR) alpha and delta. EC50 values were 45 and 175 nM, respectively. GFT505 is being developed as a dual PPAR-α/PPAR-δ receptor agonist for the treatment of type 2 diabetes and nonalcoholic fatty liver disease. GFT1007 and GFT505 have an active metabolite, both with potent stimulant activity PPAR-α and to a lesser extent PPAR-δ.

Biological Activity

Elafibranor (GFT505) is an agonist of PPAR-alpha and PPAR-delta, improves insulin sensitivity, benefits glucose homeostasis, lipid metabolism and reduces inflammation.

References

1) Cariou?et al.?(2011)?Effects of the New Dual PPARα/δ Agonist GFT505 on Lipid and Glucose Homeostasis in Abdominally Obese Patients With Combined Dyslipidemia or Impaired Glucose Metabolism; Diabetes Care?34?2008 2) Cariou?et al.?(2013)?Dual peroxisome proliferator receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects; Diabetes Care?36?2923 3) Hanf?et al.?(2014)?The dual peroxisome proliferator-activated alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.; Diab. Vasc. Dis. Res.?11?440 4) Staels?et al.?(2013)?Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha-delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis; Hepatology?58?1941 5) Ratziu?et al.?(2016)?Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.; Gastroenterology.?39?2951 6) Boeckmans?et al. (2019)?Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH.; Pharmacol. Res.?114?377

Elafibranor(GFT505) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Elafibranor(GFT505) manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Elafibranor(GFT505) 923978-27-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-01-02

Career Henan Chemical Co

Product: Elafibranor(GFT505) 923978-27-2
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100MT
Release date: 2018-12-15

923978-27-2, Elafibranor(GFT505)Related Search:

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Elafibranor(GFT505)

elafibranor E

Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methyl-

2-[2,6-Dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methylpropanoic acid

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SureCN815512

Elafibranor (GFT-505, Ph III)

GFT505(ELAFIBRANOR)

ELAFIBRANOR;GF T505;GFT-505;GFT505

CS-2411

GFT505; GFT-505; GFT 505;

Elafibranor(GFT505) ISO 9001：2015 REACH

Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-

inhibit,Elafibranor,PPAR,GFT-505,Peroxisome proliferator-activated receptors,GFT 505,Inhibitor

923978-27-2

C22H24O4S