A-196

Product Name: A-196
CAS No.: 1982372-88-2
Chemical Name: A-196
Synonyms: A-196;SGC A-196;A-196 (A196;A-196;A 196;A196;A196,Histone Methyltransferase,A-196,Inhibitor,inhibit;6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine;6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine;1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-
CBNumber: CB43051065
Molecular Formula: C18H16Cl2N4
Formula Weight: 359.25
MOL File: 1982372-88-2.mol

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A-196 Property

Boiling point:: 584.6±45.0 °C(Predicted)
Density: 1.399±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 5 mg/ml)
form: powder
pka: 3.96±0.30(Predicted)
color: white to light brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1565
Product name: A-196
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $117
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1565
Product name: A-196
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $382
Updated: 2023/06/20

Cayman Chemical

Product number: 18317
Product name: A-196
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18317
Product name: A-196
Purity: ≥98%
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 18317
Product name: A-196
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

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A-196 Chemical Properties,Usage,Production

Description

A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC₅₀s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC₅₀ values less than 1 μM. For more information on A-196 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2043 (A-197), for A-196 is also available exclusively through the SGC. You can submit a request to receive the negative control here.

Uses

A-196 is a potent inhibitor of SUV420H1.

Biochem/physiol Actions

A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. For full characterization details, please visit the A-196 probe summary on the Structural Genomics Consortium (SGC) website.SGC2043 is the negative control for the active probe, A-196. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

References

1) Bromberg?et al.?(2017),?The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol.?13?317

A-196 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-196 Suppliers

China 51 India 1 United Kingdom 1 United States 7 USA 1 Global 61

Haoyuan Chemexpress Co., Ltd.

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Sigma-Aldrich

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1982372-88-2, A-196Related Search:

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A-196

A-196;A 196;A196

A-196 (A196

6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine

1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-

SGC A-196

6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine

A196,Histone Methyltransferase,A-196,Inhibitor,inhibit

1982372-88-2