CHK2 INHIBITOR II
- Product Name
- CHK2 INHIBITOR II
- CAS No.
- 516480-79-8
- Chemical Name
- CHK2 INHIBITOR II
- Synonyms
- C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;BML-277 (C 3742);C 3742 BML-277;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II hydrate;Chk2 Inhibitor II (BML-277)
- CBNumber
- CB9503256
- Molecular Formula
- C20H14ClN3O2
- Formula Weight
- 363.8
- MOL File
- 516480-79-8.mol
CHK2 INHIBITOR II Property
- Boiling point:
- 637.1±63.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 18 mg/mL
- form
- solid
- pka
- 10.40±0.10(Predicted)
- color
- tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 220486
- Product name
- Chk2 Inhibitor II
- Packaging
- 1mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 220491
- Product name
- InSolution? Chk2 Inhibitor II
- Packaging
- 5mg
- Price
- $280
- Updated
- 2023/01/07
- Product number
- 17552
- Product name
- Chk2 Inhibitor II
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17552
- Product name
- Chk2 Inhibitor II
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- C3742
- Product name
- Chk2 Inhibitor II hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $220
- Updated
- 2024/03/01
CHK2 INHIBITOR II Chemical Properties,Usage,Production
Description
Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
Uses
Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
References
1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873 2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819
CHK2 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CHK2 INHIBITOR II manufacturers
- Product
- CHK2 INHIBITOR II 516480-79-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05