A-196
- Product Name
- A-196
- CAS No.
- 1982372-88-2
- Chemical Name
- A-196
- Synonyms
- A-196;SGC A-196;A-196 (A196;A-196;A 196;A196;A196,Histone Methyltransferase,A-196,Inhibitor,inhibit;6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine;6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine;1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-
- CBNumber
- CB43051065
- Molecular Formula
- C18H16Cl2N4
- Formula Weight
- 359.25
- MOL File
- 1982372-88-2.mol
A-196 Property
- Boiling point:
- 584.6±45.0 °C(Predicted)
- Density
- 1.399±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 5 mg/ml)
- form
- powder
- pka
- 3.96±0.30(Predicted)
- color
- white to light brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety
- RIDADR
- UN 2811 6.1 / PGIII
N-Bromosuccinimide Price
- Product number
- SML1565
- Product name
- A-196
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $117
- Updated
- 2023/06/20
- Product number
- SML1565
- Product name
- A-196
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $382
- Updated
- 2023/06/20
- Product number
- 18317
- Product name
- A-196
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18317
- Product name
- A-196
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 18317
- Product name
- A-196
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
A-196 Chemical Properties,Usage,Production
Description
A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC50s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC50 values less than 1 μM. For more information on A-196 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2043 (A-197), for A-196 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
Uses
A-196 is a potent inhibitor of SUV420H1.
Biochem/physiol Actions
A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. For full characterization details, please visit the A-196 probe summary on the Structural Genomics Consortium (SGC) website.SGC2043 is the negative control for the active probe, A-196. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at +4°C
References
1) Bromberg?et al.?(2017),?The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol.?13?317
A-196 Preparation Products And Raw materials
Raw materials
Preparation Products
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