ChemicalBook > CAS DataBase List > Biotin-PEG2-Acid

Biotin-PEG2-Acid

Product Name
Biotin-PEG2-Acid
CAS No.
1365655-89-5
Chemical Name
Biotin-PEG2-Acid
Synonyms
Biotin-PEG2-Acid;Biotin-PEG2-COOH;Biotin PEG2-C2-COOH;(+)-Biotin-PEG2-acid;(+)-Biotin-PEG2-CH2CH2COOH;3-(2-(2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)propanoic acid;Propanoic acid, 3-[2-[2-[[5-[(3aR,4R,6aS)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]-, rel-
CBNumber
CB43062388
Molecular Formula
C17H29N3O6S
Formula Weight
403.49
MOL File
1365655-89-5.mol
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Biotin-PEG2-Acid Property

Boiling point:
752.2±60.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
-20°C, protect from light, stored under argon
solubility 
Soluble in DMSO, DMF
pka
4.28±0.10(Predicted)
form 
solid
color 
White
InChIKey
SDOAIZRTYJIBBG-RMBTXETHNA-N
SMILES
C(O)(=O)CCOCCOCCNC(=O)CCCC[C@@H]1[C@]2([H])NC(=O)N[C@]2([H])CS1 |&1:18,19,25,r|
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-20613
Product name
Biotin-PEG2-acid
Purity
98%
Packaging
100mg
Price
$150
Updated
2021/12/16
BroadPharm
Product number
BP-20613
Product name
Biotin-PEG2-acid
Purity
98%
Packaging
500mg
Price
$390
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
POL0002383
Product name
BIOTIN-PEG2-ACID
Purity
95.00%
Packaging
5MG
Price
$499.66
Updated
2021/12/16
BroadPharm
Product number
BP-20613
Product name
Biotin-PEG2-acid
Purity
98%
Packaging
1g
Price
$545
Updated
2021/12/16
purepeg
Product number
246802
Product name
(+)-Biotin-PEG2-CH2CH2COOH
Purity
min.97%
Packaging
250mg
Price
$180
Updated
2021/12/16
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Biotin-PEG2-Acid Chemical Properties,Usage,Production

Description

Biotin-PEG2-acid is reactive with amine-containing macromolecule. The hydrophilic PEG arm improves water solubility. The biotin groups serve as an affinity label towards the proteins avidin and streptavidin.

Uses

Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC 50

PEGs; Non-cleavable Linker

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Biotin-PEG2-Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Biotin-PEG2-Acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Biotin-PEG2-COOH 1365655-89-5
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-30