ChemicalBook > CAS DataBase List > 4BP-TQS

4BP-TQS

Product Name
4BP-TQS
CAS No.
360791-49-7
Chemical Name
4BP-TQS
Synonyms
4BP-TQS;4BP-TQS >=98% (HPLC);4BP-TQS, 10 mM in DMSO;3H-Cyclopenta[c]quinoline-8-sulfonamide, 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-;4BP TQS,allosteric agonist,transmembrane site,Inhibitor,α7 nAChR,inhibit,Nicotinic acetylcholine receptors,4BPTQS,nAChR,4BP-TQS
CBNumber
CB43067530
Molecular Formula
C18H17BrN2O2S
Formula Weight
405.31
MOL File
360791-49-7.mol
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4BP-TQS Property

Melting point:
>202°C (dec.)
Boiling point:
566.2±60.0 °C(Predicted)
Density 
1.505±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
powder
pka
10.21±0.40(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1167
Product name
4BP-TQS
Purity
≥98% (HPLC)
Packaging
25mg
Price
$369
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1167
Product name
4BP-TQS
Purity
≥98% (HPLC)
Packaging
5mg
Price
$102
Updated
2022/05/15
Cayman Chemical
Product number
21881
Product name
4BP-TQS
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21881
Product name
4BP-TQS
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
21881
Product name
4BP-TQS
Packaging
10mg
Price
$184
Updated
2024/03/01
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4BP-TQS Chemical Properties,Usage,Production

Uses

4BP-TQS is an agonist of human α7 nicotinic acetylcholine receptor (a7-nAChR), activates the channel via binding to an allosteric transmembrane site. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.

Biochem/physiol Actions

4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.

4BP-TQS Preparation Products And Raw materials

Raw materials

Preparation Products

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4BP-TQS Suppliers

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360791-49-7, 4BP-TQSRelated Search:


  • 4BP-TQS
  • 3H-Cyclopenta[c]quinoline-8-sulfonamide, 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-
  • 4BP-TQS >=98% (HPLC)
  • 4BP TQS,allosteric agonist,transmembrane site,Inhibitor,α7 nAChR,inhibit,Nicotinic acetylcholine receptors,4BPTQS,nAChR,4BP-TQS
  • 4BP-TQS, 10 mM in DMSO
  • 360791-49-7