4BP-TQS
- Product Name
- 4BP-TQS
- CAS No.
- 360791-49-7
- Chemical Name
- 4BP-TQS
- Synonyms
- 4BP-TQS;4BP-TQS >=98% (HPLC);3H-Cyclopenta[c]quinoline-8-sulfonamide, 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-;4BP TQS,allosteric agonist,transmembrane site,Inhibitor,α7 nAChR,inhibit,Nicotinic acetylcholine receptors,4BPTQS,nAChR,4BP-TQS
- CBNumber
- CB43067530
- Molecular Formula
- C18H17BrN2O2S
- Formula Weight
- 405.31
- MOL File
- 360791-49-7.mol
4BP-TQS Property
- Melting point:
- >202°C (dec.)
- Boiling point:
- 566.2±60.0 °C(Predicted)
- Density
- 1.505±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- powder
- pka
- 10.21±0.40(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1167
- Product name
- 4BP-TQS
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $359
- Updated
- 2024/03/01
- Product number
- SML1167
- Product name
- 4BP-TQS
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $102
- Updated
- 2022/05/15
- Product number
- 21881
- Product name
- 4BP-TQS
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21881
- Product name
- 4BP-TQS
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 21881
- Product name
- 4BP-TQS
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
4BP-TQS Chemical Properties,Usage,Production
Uses
4BP-TQS is an agonist of human α7 nicotinic acetylcholine receptor (a7-nAChR), activates the channel via binding to an allosteric transmembrane site. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.
Biochem/physiol Actions
4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.