HYDROXYFLUTAMIDE

ChemicalBook > CAS DataBase List > HYDROXYFLUTAMIDE

Product Name: HYDROXYFLUTAMIDE
CAS No.: 52806-53-8
Chemical Name: HYDROXYFLUTAMIDE
Synonyms: CS-1970;utamide;Sch-16423;Hydroxy FL;Hydroxyflutamid;HYDROXYFLUTAMIDE;hydroxyniphtholide;5-HYDROXYFLUTAMIDE;2-HYDROXY-FLUTAMIDE;Flutamide Impurity 7
CBNumber: CB4307190
Molecular Formula: C11H11F3N2O4
Formula Weight: 292.21
MOL File: 52806-53-8.mol

Less

HYDROXYFLUTAMIDE Property

Melting point:: 125-130°C
Boiling point:: 443.8±45.0 °C(Predicted)
Density: 1.472
storage temp.: room temp
solubility: DMSO: >10mg/mL
pka: 12.87±0.70(Predicted)
form: powder
color: white to tan

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
RTECS: TX1466250
HS Code: 2924297099

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4166
Product name: Hydroxyflutamide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4166
Product name: Hydroxyflutamide
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $557
Updated: 2024/03/01

TCI Chemical

Product number: H1600
Product name: Hydroxyflutamide
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $278
Updated: 2024/03/01

TCI Chemical

Product number: H1600
Product name: Hydroxyflutamide
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $830
Updated: 2024/03/01

Cayman Chemical

Product number: 15271
Product name: 2-hydroxy Flutamide
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Less

HYDROXYFLUTAMIDE Chemical Properties,Usage,Production

Description

2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC₅₀ = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR. Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.

Chemical Properties

HYDROXYFLUTAMIDE is Yellow-Brown Powder

Uses

HYDROXYFLUTAMIDE is used non-steroidal antagonist Flutamide. Shown to be an antianhydrogen.

Uses

The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.

Uses

Shown to be an antianhydrogen. The active metabolite of the widely used non-steroidal antagonist flutamide

Biochem/physiol Actions

Hydroxyflutamide plays a role in preventing the binding of 5α-dihydrotestosterone (DHT) and testosterone to the androgen receptors.

References

[1] kolvenbag g, furr b j a, blackledge g r p. receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity[j]. prostate cancer and prostatic diseases, 1998, 1: 307-314.
[2] heinlein c a, chang c. androgen receptor in prostate cancer[j]. endocrine reviews, 2004, 25(2): 276-308.
[3] shet m s, mcphaul m, fisher c w, et al. metabolism of the antiandrogenic drug (flutamide) by human cyp1a2[j]. drug metabolism and disposition, 1997, 25(11): 1298-1303.
[4] gao w, kim j, dalton j t. pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands[j]. pharmaceutical research, 2006, 23(8): 1641-1658.

HYDROXYFLUTAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

HYDROXYFLUTAMIDE Suppliers

Americas 1 Canada 2 China 80 Europe 1 Germany 1 India 6 Ireland 1 Japan 1 Switzerland 1 United Kingdom 8 United States 25 Global 127

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4271
Advantage: 65

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: +8613162137806 18575662672
Fax: 021 51613951
Email: mzeng@3wpharm.com
Country: China
ProdList: 9743
Advantage: 57

Wuhan ariel chemical Co., LTD.

Tel: 18986259541 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3940
Advantage: 58

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1076
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 18017383231 18017383231
Fax: qq：2817624287
Email: lyh_antaeus@163.com
Country: China
ProdList: 9352
Advantage: 55

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1958
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5936
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Struchem Co., Ltd.

Tel: 0512-0512-63009836 15365350169
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3988
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1503
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: 571-85586718 +8613336195806
Fax: +86-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 29797
Advantage: 60

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: (5)02557626880
Email: cb6@aikonchem.com
Country: China
ProdList: 15495
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 18521078705
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 19981
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 18016230971
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24971
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55936
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9997
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Nanjing Ze Feng biological medicine technology Co., Ltd.

Tel: 18851912129; 18851912129
Email: 1670471576@qq.com
Country: China
ProdList: 1033
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Wuhan xinyangruihe Chemical Technology Co., Ltd.

Tel: 027-83855316 18171155316
Fax: 027-83855316
Email: 3317533608@qq.com
Country: China
ProdList: 2784
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 15093356674;
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29826
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038; 18501792038
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9614
Advantage: 58

Nanjing shengyilai Chemical Co., Ltd

Tel: 19951936396
Email: 3158688292@qq.com
Country: China
ProdList: 4840
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4196
Advantage: 58

CHG Opto-Electronic Corporation Limited

Tel: 2537653158 16621191650
Fax: QQ 2537653158
Email: 2537653158@qq.com
Country: China
ProdList: 7348
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 9946
Advantage: 58

Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.

Tel: 025-025-58280381 15720605021
Fax: QQ：353175721
Email: zhang_lei@jsnchem.com
Country: China
ProdList: 1510
Advantage: 58

Hebei Zhenjia new material Co., LTD

Tel: 0319-5925599 13315915972
Email: 13313090628@163.com
Country: China
ProdList: 3479
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6713
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002
Email: zhejia01@163.com
Country: China
ProdList: 8871
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7722
Advantage: 58

Beijing Jianuode Pharmaceutical Technology Co., Ltd.

Tel: 010-67267894 18611880885
Email: gianord@163.com
Country: China
ProdList: 31
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 11572
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27996
Advantage: 58

Anhui Yongsheng Pharmaceutical Technology Co., Ltd

Tel: 18017383231
Email: 1849315414@qq.com
Country: China
ProdList: 807
Advantage: 58

Shanghai Jianchao Biotechnology Co., LTD

Tel: 13621743886 13621743886
Email: 3366408901@qq.com
Country: China
ProdList: 3821
Advantage: 58

Less

View Lastest Price from HYDROXYFLUTAMIDE manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Hydroxyflutamide；2-Hydroxyflutamide 52806-53-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-13

Career Henan Chemical Co

Product: HYDROXYFLUTAMIDE 52806-53-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 100kg
Release date: 2019-12-25

52806-53-8, HYDROXYFLUTAMIDERelated Search:

Flutamide Sildenafil 2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (2-HYDROXYFLUTAMIDE) HYDROXYFLUTAMIDE, [3H]- 2-(Trifluoromethyl)benzene-1,4-diamine 4-Nitro-3-trifluoromethyl aniline 2-Amino-5-acetamidobenzotrifluoride 2-METHYL-D3-N-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-2-TRIMETHYLSILYLOXY-PROPAMIDE-3,3,3-D3 HYDROXYFLUTAMIDE Hydroxy FlutaMide-d6 4-ACETAMIDO-2-METHYLNITROBENZENE 4'-NITRO-3'-(TRIFLUOROMETHYL)ACETANILIDE N-(4-AMINO-3-METHYLPHENYL)PROPANAMIDE

2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-propanamid

hydroxyniphtholide

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide

Hydroxy-Flutamide(Flutamide metabolite)

5-Hydroxyflutamide, 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide,

5-HYDROXYFLUTAMIDE

CS-1970

HYDROXYFLUTAMIDE (2-HYDROXY-2-METHYL-N-{4''-NITRO-3''-(TRIFLUOROMETHYL)PHENYL}PROPANAMIDE)

α,α,α-Trifluoro-2-Methyl-4'-nitro-M- lactotoluidide

HydroxyflutaMide (Hydroxyniphtholide)

a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide

Hydroxyflutamide, >=98%

2-Hydroxy-2-methyl-N-(3-trifluoromethyl-4-nitrophenyl)propanamide

Hydroxyflutamid

N-[3-(Trifluoromethyl)-4-nitrophenyl]-2-hydroxyisobutyramide

Sch-16423

alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide

Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-

HYDROXYFLUTAMIDE

2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]-PROPANAMIDE

2-HYDROXY-FLUTAMIDE

2-Hydroxy-2-methyl-N-[4-nitro-3-(tr

Hydroxy FL

utamide

Flutamide Hydroxy Impurity

2-Hydroxy-4'-nitro-3'-(trifluoromethyl)isobutyranilide

Flutamide Impurity 7

2-Hydroxyflutamide (Hydroxyniphtholide)

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop

Inhibitor,inhibit,prostate cancer,HFT,Flutamide,2 hydroxy Flutamide,2hydroxy Flutamide,Androgen Receptor,Hydroxyflutamide

52806-53-8

Amines

Aromatics

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Various Metabolites and Impurities

Inhibitors

Metabolites