HYDROXYFLUTAMIDE

ChemicalBook > CAS DataBase List > HYDROXYFLUTAMIDE

Product Name: HYDROXYFLUTAMIDE
CAS No.: 52806-53-8
Chemical Name: HYDROXYFLUTAMIDE
Synonyms: CS-1970;utamide;Sch-16423;Hydroxy FL;Hydroxyflutamid;HYDROXYFLUTAMIDE;hydroxyniphtholide;5-HYDROXYFLUTAMIDE;2-HYDROXY-FLUTAMIDE;Flutamide Impurity 7
CBNumber: CB4307190
Molecular Formula: C11H11F3N2O4
Formula Weight: 292.21
MOL File: 52806-53-8.mol

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HYDROXYFLUTAMIDE Property

Melting point:: 125-130°C
Boiling point:: 443.8±45.0 °C(Predicted)
Density: 1.472
storage temp.: room temp
solubility: DMSO: >10mg/mL
pka: 12.87±0.70(Predicted)
form: powder
color: white to tan

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
RTECS: TX1466250
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4166
Product name: Hydroxyflutamide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4166
Product name: Hydroxyflutamide
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $557
Updated: 2024/03/01

TCI Chemical

Product number: H1600
Product name: Hydroxyflutamide
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $278
Updated: 2024/03/01

TCI Chemical

Product number: H1600
Product name: Hydroxyflutamide
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $830
Updated: 2024/03/01

Cayman Chemical

Product number: 15271
Product name: 2-hydroxy Flutamide
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

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HYDROXYFLUTAMIDE Chemical Properties,Usage,Production

Description

2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC₅₀ = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR. Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.

Chemical Properties

HYDROXYFLUTAMIDE is Yellow-Brown Powder

Uses

HYDROXYFLUTAMIDE is used non-steroidal antagonist Flutamide. Shown to be an antianhydrogen.

Uses

The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.

Uses

Shown to be an antianhydrogen. The active metabolite of the widely used non-steroidal antagonist flutamide

Biochem/physiol Actions

Hydroxyflutamide plays a role in preventing the binding of 5α-dihydrotestosterone (DHT) and testosterone to the androgen receptors.

References

[1] kolvenbag g, furr b j a, blackledge g r p. receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity[j]. prostate cancer and prostatic diseases, 1998, 1: 307-314.
[2] heinlein c a, chang c. androgen receptor in prostate cancer[j]. endocrine reviews, 2004, 25(2): 276-308.
[3] shet m s, mcphaul m, fisher c w, et al. metabolism of the antiandrogenic drug (flutamide) by human cyp1a2[j]. drug metabolism and disposition, 1997, 25(11): 1298-1303.
[4] gao w, kim j, dalton j t. pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands[j]. pharmaceutical research, 2006, 23(8): 1641-1658.

HYDROXYFLUTAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HYDROXYFLUTAMIDE manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Hydroxyflutamide；2-Hydroxyflutamide 52806-53-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-13

Career Henan Chemical Co

Product: HYDROXYFLUTAMIDE 52806-53-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 100kg
Release date: 2019-12-25

52806-53-8, HYDROXYFLUTAMIDERelated Search:

Flutamide Sildenafil 2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (2-HYDROXYFLUTAMIDE) HYDROXYFLUTAMIDE, [3H]- 2-(Trifluoromethyl)benzene-1,4-diamine 4-Nitro-3-trifluoromethyl aniline 2-Amino-5-acetamidobenzotrifluoride 2-METHYL-D3-N-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-2-TRIMETHYLSILYLOXY-PROPAMIDE-3,3,3-D3 HYDROXYFLUTAMIDE Hydroxy FlutaMide-d6 4-ACETAMIDO-2-METHYLNITROBENZENE 4'-NITRO-3'-(TRIFLUOROMETHYL)ACETANILIDE N-(4-AMINO-3-METHYLPHENYL)PROPANAMIDE

2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-propanamid

hydroxyniphtholide

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide

Hydroxy-Flutamide(Flutamide metabolite)

5-Hydroxyflutamide, 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide,

5-HYDROXYFLUTAMIDE

CS-1970

HYDROXYFLUTAMIDE (2-HYDROXY-2-METHYL-N-{4''-NITRO-3''-(TRIFLUOROMETHYL)PHENYL}PROPANAMIDE)

α,α,α-Trifluoro-2-Methyl-4'-nitro-M- lactotoluidide

HydroxyflutaMide (Hydroxyniphtholide)

a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide

Hydroxyflutamide, >=98%

2-Hydroxy-2-methyl-N-(3-trifluoromethyl-4-nitrophenyl)propanamide

Hydroxyflutamid

N-[3-(Trifluoromethyl)-4-nitrophenyl]-2-hydroxyisobutyramide

Sch-16423

alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide

Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-

HYDROXYFLUTAMIDE

2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]-PROPANAMIDE

2-HYDROXY-FLUTAMIDE

2-Hydroxy-2-methyl-N-[4-nitro-3-(tr

Hydroxy FL

utamide

Flutamide Hydroxy Impurity

2-Hydroxy-4'-nitro-3'-(trifluoromethyl)isobutyranilide

Flutamide Impurity 7

2-Hydroxyflutamide (Hydroxyniphtholide)

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop

Inhibitor,inhibit,prostate cancer,HFT,Flutamide,2 hydroxy Flutamide,2hydroxy Flutamide,Androgen Receptor,Hydroxyflutamide

52806-53-8

Amines

Aromatics

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Various Metabolites and Impurities

Inhibitors

Metabolites