ChemicalBook > CAS DataBase List > 4-Nitro-3-trifluoromethyl aniline

4-Nitro-3-trifluoromethyl aniline

Product Name
4-Nitro-3-trifluoromethyl aniline
CAS No.
393-11-3
Chemical Name
4-Nitro-3-trifluoromethyl aniline
Synonyms
FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;Linagliptin Impurity CD10103;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE
CBNumber
CB4483928
Molecular Formula
C7H5F3N2O2
Formula Weight
206.12
MOL File
393-11-3.mol
More
Less

4-Nitro-3-trifluoromethyl aniline Property

Melting point:
125-129 °C (lit.)
Boiling point:
326.4±42.0 °C(Predicted)
Density 
1.4711 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
-0.22±0.10(Predicted)
color 
Yellow to Orange-Yellow
BRN 
2650702
InChIKey
UTKUVRNVYFTEHF-UHFFFAOYSA-N
CAS DataBase Reference
393-11-3(CAS DataBase Reference)
NIST Chemistry Reference
5-Amino-2-nitrobenzotrifluoride(393-11-3)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37
WGK Germany 
2
Hazard Note 
Irritant
HS Code 
29214200
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A68807
Product name
4-Nitro-3-(trifluoromethyl)aniline
Purity
98%
Packaging
5g
Price
$57.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1285997
Product name
Flutamide Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1300
Updated
2024/03/01
TCI Chemical
Product number
A0377
Product name
5-Amino-2-nitrobenzotrifluoride
Purity
>98.0%(GC)
Packaging
5g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
A0377
Product name
5-Amino-2-nitrobenzotrifluoride
Purity
>98.0%(GC)
Packaging
25g
Price
$60
Updated
2024/03/01
Alfa Aesar
Product number
A13798
Product name
4-Nitro-3-(trifluoromethyl)aniline, 98%
Packaging
1g
Price
$31.65
Updated
2024/03/01
More
Less

4-Nitro-3-trifluoromethyl aniline Chemical Properties,Usage,Production

Description

4-Nitro-3-trifluoromethyl aniline is an organic intermediate, which can be used to prepare 4-bromo-2-nitrotrifluorotoluene, an intermediate of medicine and optical waveguide materials, and flutamide, a non steroidal anti androgen drug.

Chemical Properties

Orange to Brown to Dark red powder to crystal.

Uses

4-Nitro-3-(trifluoromethyl)aniline is a metabolite of Flutamide (F598850) (FLU-1 or M2).

Uses

A metabolite of Flutamide (FLU-1 or M2).

Synthesis

The thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of 1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in degassed THF (0.50 mL) under argon at r.t. The resulting suspension was stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in one portion, and the mixture was stirred (Table 2). Water (2 mL) was added, and the products were extracted with EtOAc (2 ?á 2 mL), the combined organic phase was dried over anhyd MgSO4, filtered, and concentrated in vacuo. Purification was achieved by passing the resulting residue through a short pad of silica (eluting with 50% light PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit., 92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.

Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline

4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Nitro-3-trifluoromethyl aniline Suppliers

Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com
Country
China
ProdList
2540
Advantage
64
Hengshui juming chemical technology co., ltd
Tel
13785838008
Email
admin@junrunchem.com
Country
China
ProdList
7
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Liaoning Tianhua Chemical Co., Ltd.
Tel
0418-6530555 2855550
Fax
+86-418-6502885
Country
China
ProdList
338
Advantage
69
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
More
Less

View Lastest Price from 4-Nitro-3-trifluoromethyl aniline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Nitro-3-trifluoromethyl aniline 393-11-3
Price
US $0.00-0.00/KG
Min. Order
50mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-08
Hebei Weibang Biotechnology Co., Ltd
Product
4-NITRO-3-TRIFLUOROMETHYL ANILINE 393-11-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100
Release date
2024-10-30
Wuhan Cell Pharmaceutical Co., Ltd
Product
4-Nitro-3-trifluoromethyl aniline 393-11-3
Price
US $7.00-123.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-03-29

393-11-3, 4-Nitro-3-trifluoromethyl anilineRelated Search:


  • 4-Nitro-3-Triflouromethyl Aniline (Flutamide Intermediate)
  • Flutamide ImpurityⅠ:4-Nitro-3-(trifluoromethyl)aniline
  • α,α,α-Trifluoro-4-nitro-m-toluidine
  • 4-nitro-3-(trifluoromethyl)benzeneamine
  • Flutamide Impurity A
  • 4-Nitro-α,α,α
  • 4-Nitro-3-(trifluoromethyl)aniline (FLU-1)
  • 5-Amino-2-nitrobenzotrifluoride, 4-Nitro-α,α,α-trifluoro-m-toluidine
  • 4-nitro-3-(trifluoromethyl)benzenamine
  • FLU-1
  • 4-Nitro-3-(trifluoromethyl)aniline ,98%
  • FlutaMide Related CoMpound A
  • The 4- nitro-3- threetrifluoroMethylaniline
  • 4-Nitro-4-(trifluoromethyl)aniline
  • Flutamide Related Compound A (20 mg) (4-nitro-3-(trifluoromethyl)aniline)
  • 4-Nitro-3-(trifluoromethyl)aniline 98%
  • 2-NITRO-5-AMINO BENZOTRIFLUORIDE
  • 5-AMINO-2-NITROBENZOTRIFLUORIDE
  • 4-NITRO-3-(TRIFLUOROMETHYL)ANILINE
  • 4-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE
  • 3-AMINO-6-NITROBENZOTRIFLUORIDE
  • TIMTEC-BB SBB006652
  • 2-Nitro-5-aminobenzotriluoride
  • Benzenamine, 4-nitro-3-(trifluoromethyl)-
  • 4-Nitro-α,α,α-trifluoro-m-toluidine
  • 3-Trifluoromethyl-4-nitroaniline
  • 4-Nitro-3-(trifluoromethyl) aniline (3-Amino-6-nitrobenzotrifluoride)
  • 4-Nitro-3-aminobenzotrifluoride
  • 4-Nitro-3-trifluoromethylaniline(Flutamide impurity)
  • 5-Amino-2-nitrobenzotrifluoride,97%
  • 5-Amino-2-nitrobenzotrifluoride 98%
  • 5-Amino-2-nitrobenzotrifluoride98%
  • 2-NITRO-5-AMINOBENZOTRIFLUORIDE(3-TRIFLUOROMETHYL-4-NITROANILINE)
  • 3-trifluoromethyl-4-nitroanilide
  • 4-Nitro-3-(trifluormethyl)anilin
  • 3-trifluoromethyl-4-nitroaniune
  • 5-Amino-2-nitrobenzotrifluoride &gt
  • Nilutamide impurity B CRS
  • Nilutamide Impurity 3
  • 4-NITRO-3-TRIFLUOROMETHYL ANILINE CAS NO 393-11-3
  • Flutamide Impurity 1 (Flutamide EP Impurity A)
  • TIANFU-CHEM 4-Nitro-3-trifluoromethyl aniline
  • Flutamide Related Compound A (4-nitro-3-(trifluoromethyl)aniline) (1285997)
  • Flutamide USP Related Compound A
  • 4-nitro-3-(trifluoromethyl)aniline (nifeline)
  • Flutamide EP Impurity A(Nilutamide EP Impurity B)
  • 4-Nitro-3-(trifluoromethyl0aniline
  • Linagliptin Impurity CD10103
  • 393-11-3
  • Organic Building Blocks
  • Nitrogen Compounds
  • C7
  • Amines
  • Building Blocks
  • Anilines, Aromatic Amines and Nitro Compounds
  • Amines
  • Phenyls & Phenyl-Het
  • Phenyls & Phenyl-Het