ChemicalBook > CAS DataBase List > 4'-Nitroacetanilide

4'-Nitroacetanilide

Product Name
4'-Nitroacetanilide
CAS No.
104-04-1
Chemical Name
4'-Nitroacetanilide
Synonyms
NSC 1315;P-NITROACETANILIDE;p-nitro-acetanilid;4-NITROACETANILIDE;4'-NITROACETANILIDE;4'-Nitroacetanilide;Acetanilide, p-nitro-;acetanilide,4’-nitro-;4-Nitroacetanilide 98%;LABOTEST-BB LT00455738
CBNumber
CB1191136
Molecular Formula
C8H8N2O3
Formula Weight
180.16
MOL File
104-04-1.mol
More
Less

4'-Nitroacetanilide Property

Melting point:
213-215 °C(lit.)
Boiling point:
312.97°C (rough estimate)
Density 
1.340
refractive index 
1.6180 (estimate)
storage temp. 
Store below +30°C.
solubility 
2.2g/l
form 
Solid
pka
13.91±0.70(Predicted)
color 
Yellow to green-yellow or green-brown
Water Solubility 
2.2g/L(room temperature)
Merck 
14,6581
BRN 
2211962
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
104-04-1(CAS DataBase Reference)
EPA Substance Registry System
Acetamide, N-(4-nitrophenyl)- (104-04-1)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AE5075000
TSCA 
Yes
HS Code 
29242990
Toxicity
rat,LDLo,intraperitoneal,500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 10, 1953.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20880
Product name
4′-Nitroacetanilide
Purity
for synthesis
Packaging
25G
Price
$53.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20880
Product name
4′-Nitroacetanilide
Purity
for synthesis
Packaging
100G
Price
$204
Updated
2024/03/01
Sigma-Aldrich
Product number
130648
Product name
4-Nitroacetanilide
Purity
98%
Packaging
5g
Price
$41.6
Updated
2024/03/01
TCI Chemical
Product number
N0108
Product name
4'-Nitroacetanilide
Purity
>99.0%(GC)
Packaging
25g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
N0108
Product name
4'-Nitroacetanilide
Purity
>99.0%(GC)
Packaging
500g
Price
$673
Updated
2024/03/01
More
Less

4'-Nitroacetanilide Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Manufacture of nitraniline.

Uses

4-Nitroacetanilide was used as a test substrate and its hydrolysis was determined by UV spectroscopic measurements. It was also used to prepare 4-aminoacetanilide.

Preparation

Preparation of 4'-Nitroacetanilide from acetanilide.
Principle: Aromatic compounds can be conveniently nitrated by the use of the nitrating mixture, which is normally a mixture of concentrated nitric acid and concentrated sulphuric acid. The function of sulphuric acid is to convert nitric acid into a highly reactive, electrophilic, nitronium ion, NO2+, which is the effective nitrating agent. Nitration of activated aromatic compounds is carried out under milder condition whereas deactivated rings require drastic conditions. Activating groups are o, p-directing, while deactivating groups are m-directing for electrophilic substitution.
Reaction:

Procedure: Take 0.5 g acetanilide in 0.6 ml glacial acetic acid and add 1 ml conc. H2SO4 in a beaker. Cool the mixture in ice salt bath (5-10°C). To this add a mixture of 0.2 ml conc. H2SO4 and 0.25 ml conc. HNO3 dropwise. Maintain the temperature below 10°C during addition. After addition is over allow the mixture to attain room temperature and leave it for 30 minutes. Pour the mixture on to crushed ice (20 g) with stirring. Filter the separated product and wash with cold water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC (using toluene as solvent).

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 5905, 1953 DOI: 10.1021/ja01119a037
Tetrahedron Letters, 28, p. 1669, 1987 DOI: 10.1016/S0040-4039(00)95389-9

Purification Methods

Precipitate the anilide from 80% H2SO4 by adding ice, then wash with water, and crystallise from aqueous EtOH. Dry it in air. [Beilstein 12 IV 1632.]

4'-Nitroacetanilide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4'-Nitroacetanilide Suppliers

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 18068193575
Fax
QQ1907456386
Email
sales11@btcpharm.com
Country
China
ProdList
1333
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
More
Less

View Lastest Price from 4'-Nitroacetanilide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4"-NITROACETANILIDE 104-04-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
4"-Nitroacetanilide 104-04-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4'-NITROACETANILIDE 104-04-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

104-04-1, 4'-NitroacetanilideRelated Search:


  • P-NITROACETANILIDE
  • N-ACETYL-4-NITROANILINE
  • 4-Nitroacetanilide, GC 97%
  • LABOTEST-BB LT00455738
  • p-nitro-acetanilid
  • p-Nitrophenylacetanilide
  • 4μ-Nitroacetanilide, Acetic acid 4-nitroanilide
  • 4'-Nitroacetanilide,97%,pract.
  • 4-(Acetylamino)nitrobenzene
  • NSC 1315
  • 4-Nitroacetanilide 98%
  • 4''-NITROACETANILIDE 99+%
  • Pera nitro Acetanilide
  • 1-Nitro-4-acetylaminobenzene
  • 4'-NITROACETANILIDE
  • 4-NITROACETANILIDE
  • ACETIC ACID 4-NITROANILIDE
  • Acetamide, N-(4-nitrophenyl)-
  • acetamide,N-(4-nitrophenyl)-
  • Acetanilide, 4'-nitro-
  • Acetanilide, p-nitro-
  • acetanilide,4’-nitro-
  • n-(4-nitrophenyl)-acetamid
  • N-(4-Nitrophenyl)acetamide
  • N-(4-Nitrophenyl)aceticacidamide
  • N-(p-Nitrophenyl)acetamide
  • N-Acetyl-4-nitrobenzenamine
  • N-Acetyl-p-nitroaniline
  • p-Acetamidonitrobenzene
  • 4'-Nitroacetanilide&gt
  • 4'-NITROACETANILIDE FOR SYNTHESIS
  • 104-04-1 C8H8N2O3 4'-NITROACETANILIDE
  • ParaNitro ACETANILIDE (PNA)
  • 4'-Nitroacetanilide
  • 104-04-1
  • Building Blocks
  • Nitrogen Compounds
  • Organic Building Blocks
  • Protected Amines
  • Intermediates of Dyes and Pigments
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Anilines, Amides & Amines
  • Nitro Compounds